Not since March 2007 have the Lakers lost five games in a row, but the defending champs could see that streak extend to six games when they face the San Antonio Spurs at Staples Center on Tuesday night.
The Spurs ended a six-game losing streak by winning four games in a row. However, three of those victories were home games against non-playoff teams.
After a slew of injuries, San Antonio is basically back at full speed, and looking to maintain the best record in the NBA with a victory in Los Angeles.
The Lakers snapped out of a string of poor shooting games against Oklahoma City on Sunday, but allowed the Thunder to shoot better than 55 percent and gave up 120 points in the loss.
Andrew Bynum has been a rebound machine for the Lakers in recent games, while Kobe Bryant and Pau Gasol have been in their usual All-Star form.
Head coach Phil Jackson will look for an increase in production from other players, as the Lakers look to hold off Dallas for the second seed in the playoffs.
The last time the Lakers and Spurs played, San Antonio was dismantled at AT&T Center in perhaps the defending champions' best game of the season.
Tony Parker, Tim Duncan, and Manu Ginobli no doubt want to avenge that loss with the Lakers looking vulnerable at the moment.
San Antonio leads the season series, 2-1.
Both the Lakers and the Spurs have one more game remaining in the regular season.
San Antonio will travel to Phoenix to face the Suns in their season finale, while the Lakers will visit the Sacramento Kings.