The game begins at 1pm eastern time and will be shown by FOX, or watch a live stream online by purchasing NFL Sunday Ticket Max.
New England and quarterback Tom Brady made quick work of the Tennessee Titans last week, winning 34-13.
The Patriots defense is on a much better pace than last season's underachieving squad. New England contained Titans running back Chris Johnson and rookie Dont'a Hightower made a huge fumble recovery for a touchdown in the second quarter in a game the Patriots controlled from opening kick-off.
Running Back Stephen Ridley lived up to lofty expectations amassing 125 yards and one touchdown on 21 carries.
Brady produced another strong game by hitting tight ends Aaron Hernandez and Rob Gronkowski for touchdowns, and went 23-for-31 for 236 yards to go with his two touchdowns.
The Cardinals faced a much more difficult task versus the Seattle Seahawks last week.
Arizona quarterback Kevin Kolb played the hero in the Cardinals win over the Seattle, as he replaced starter Jon Skelton, who was taken out due to a leg injury, and took Arizona 80 yards for the go-ahead touchdown and 20-16 victory.
His play was almost for naught as the replacement officials gave Seattle an extra timeout that should have been charged when Seahawks player was injured in the end zone in the fourth quarter. But Seattle rookie quarterback Russell Wilson failed to capitalize on several red zone passes
Kolb was given the starting nod Sunday, and will have to prove he can put together drives like he did last week if Skelton is to remain on the sideline.
Arizona's secondary may have to face the surgical strikes of Brady without cornerback Patrick Peterson and safety Adrian Wilson who are both listed as questionable.
Betting Odds: New England is favored by 14 points.
Prediction: New England has the biggest point spread of this week for good reason. The Patriots look to be in midseason form on both offense and defense, and Kolb has proven to be inconsistent throughout his entire career.
Predicted Score: New England 35, Arizona 10