Making NFL predictions in Week 2 can be difficult, trying not to overreact from just one week while figuring out which teams that surprised might actually be for real. Five underdogs, including four road teams, won straight up in Week 1 of the 2017 season.

Below are picks against the spread for every game in Week 2, as well as updated betting odds at Las Vegas and online sportsbooks. Betting lines and trends are courtesy of OddsShark.

Houston Texans (+6.5) at Cincinnati Bengals

Both teams looked so bad in Week 1 that it’s almost a no-brainer to take the points. Deshaun Watson will have trouble in his first start playing behind a bad offensive line, but the Texans’ pass rush should have their own success against the Bengals. Cincinnati is 2-7 against the spread in their last seven games against Houston, and Andy Dalton has lost three of his four matchups with the Texans.

Prediction ATS: Houston

Minnesota Vikings (+6) at Pittsburgh Steelers

Pittsburgh’s offensive weapons should ultimately be too much for Minnesota, but a win won’t come easily for the Steelers. The Vikings showed why they have a top-five defense by shutting down Drew Brees and the Saints, and Pittsburgh might have to grind out a victory like they did against Cleveland in Week 1.

Prediction ATS: Minnesota

Arizona Cardinals (-7.5) at Indianapolis Colts

The Colts are an absolute mess. Their Week 2 starting quarterback will either be one that has no career wins since joining the league in 2011 or one that was acquired less than two weeks ago. Maybe Arizona isn’t a playoff team, but they are still good enough to blow out Indianapolis, who has a bottom-three defense and possibly the league’s worst starting quarterback.

Prediction ATS: Arizona

Cleveland Browns (+8) at Baltimore Ravens

Points will be hard to come by in this one. Joe Flacco had little to do with Baltimore’s 20-0 win in Week 1, and the Ravens won’t be able to run against the Browns like they did in Cincinnati, considering Cleveland held Le’Veon Bell to 32 yards on 10 rushes. As long as DeShone Kizer avoids throwing multiple interceptions, the Browns could have a chance to win in the fourth quarter.

Prediction ATS: Cleveland

Philadelphia Eagles (+4.5) at Kansas City Chiefs

Andy Reid might not have a whole bye week to prepare for his old team, but giving him an extra couple of days won’t hurt. It’s time for Carson Wentz to prove that he can get a big win on the road after going 1-7 straight up and 2-6 against the spread away from home as a rookie. Kansas City has the personnel to nullify Philadelphia’s pass rush, as well as playmakers that can take advantage of the Eagles’ secondary.

Prediction ATS: Kansas City

Chicago Bears (+7) at Tampa Bay Buccaneers

The Bears might not win a lot of games this year, but they probably won’t be pushovers either. They’ve got a dynamic backfield with Jordan Howard and Tarik Cohen, and Mike Glennon is serviceable when he has time to throw. Tampa Bay could be rusty, having to start the season a week later than everyone else.

Prediction ATS: Chicago

Tennessee Titans (-2.5) at Jacksonville Jaguars

The Jaguars will beat the Titans if they can get 10 sacks and ask Blake Bortles to do next to nothing for a second straight week. Since that won’t happen, Tennessee has a good chance to win on the road. The Titans’ offensive line should hold up much better against Jacksonville than Houston’s did in Week 1.

Prediction ATS: Tennessee

Buffalo Bills (+7) at Carolina Panthers

Buffalo’s running game is still among the league’s best, and the Bills can remain competitive by feeding LeSean McCoy and controlling the clock. Keeping Tyrod Taylor upright will be Buffalo’s biggest challenge Sunday.

Prediction ATS: Buffalo

New England Patriots (-6.5) at New Orleans Saints

Tom Brady and Drew Brees will both be much better in Week 2 after struggling in their respective season openers. That means a lot of points for both sides and a game that should turn into a shootout. New Orleans usually scores enough to keep things close at home, and even if New England does win comfortably, a backdoor cover could be in play.

Prediction ATS: New Orleans

Miami Dolphins (+4.5) at Los Angeles Chargers

The Dolphins are in a tough spot. They have to travel across the country shortly after their season opener was canceled while dealing with the after effects of Hurricane Irma in their hometown. Don’t expect big things out of Jay Cutler, who could be under constant pressure with Joey Bosa and Melvin Ingram in his face for much of the game.

Prediction ATS: Los Angeles

New York Jets (+14) at Oakland Raiders

Picking a two-touchdown favorite is always a risky proposition, but it's hard to justify taking the Jets. The Raiders might be the second-best team in the AFC, and the addition of Marshawn Lynch has added a new dimension to their offense. Josh McCown’s 4.8 yards per pass attempt won’t be nearly enough to keep things close against Derek Carr and Oakland.

Prediction ATS: Oakland

Derek Carr Oakland Raiders Derek Carr of the Oakland Raiders runs back to his bench in the second half at Nissan Stadium on Sept. 10, 2017 In Nashville. Photo: Getty Images

Dallas Cowboys (-2) at Denver Broncos

The Cowboys have picked up where they left off last year with a top offensive line, running back and quarterback. If Dallas can slow down Denver’s pass rush like they did New York’s in Week 1, they’ll score enough points to beat Trevor Siemian and Co.

Prediction ATS: Dallas

Washington Redskins (+3) at Los Angeles Rams

These are two teams that are headed in opposite directions. After losing his top two receivers, Kirk Cousins and Washington might be the clear worst team in the NFC East. L.A. is on the rise with a new head coach and Jared Goff showing the promise of a No.1 overall draft pick. The Rams obviously won’t win by 37 points for a second straight week, but they will add arguably the NFL’s best defensive player back into the fold with the return of Aaron Donald.

Prediction ATS: Los Angeles

San Francisco 49ers (+13) at Seattle Seahawks

Seattle’s offensive line woes will be a major issue against good teams in 2017. Fortunately for the Seahawks, the 49ers don’t fall into that category. After dominating Aaron Rodgers and the Packers for most of their Week 1 matchup, Seattle’s defense should completely shut down one of the three teams that failed to score a touchdown in their season opener. The 49ers are 1-11 against the spread in their last 12 games against the Seahawks.

Prediction ATS: Seattle

Green Bay Packers (+3) at Atlanta Falcons

This isn’t going to be a repeat of last year’s NFC Championship Game. It could be a shootout that’s decided in the fourth quarter, though Atlanta’s offense isn't what it was a year ago. The Falcons were less aggressive in Week 1 without Kyle Shanahan, and that might not bode well for Atlanta against the NFC’s best quarterback.

Prediction ATS: Green Bay

Detroit Lions (+3.5) at New York Giants

Don’t pick the Giants until it’s clear that Odell Beckham is playing. There’s a good chance the wide receiver will sit again, and New York showed against Dallas how limited they are on offense without their best player. Detroit’s defense was terrific against Arizona a week ago, and even if it takes a step back in Week 2, it won’t have trouble penetrating the Giants’ offensive line.

Prediction ATS: Detroit

Season Record ATS: 5-10