Even before the weekend begins, injuries already played a major role in Week 5 with Andrew Luck being forced to sit for a second straight game. Other notable names will be sidelined on Sunday and Monday, as well.

A few top quarterbacks will be out for a few more weeks, as Ben Roethlisberger and Tony Romo continue to nurse injuries. Drew Brees and Jay Cutler returned to the field in Week 4, and they look to be good to go in Week 5.

Dez Bryant is the best playmaker that suffered a major injury this season, and is expected to return in final weeks of 2015. Jordy Nelson, who shined in 2014, suffered a season-ending injury in preseason.

Below is a look at five of the best players that are battling injuries, and their chances of suiting up in Week 5.

LeSean McCoy

For the second consecutive week, the Buffalo Bills will be without their biggest offseason acquisition. McCoy aggravated the hamstring injury that he suffered in training camp, and the team has told him that the ailment could keep him out for three or four weeks. While McCoy has been injured, running back Karlos Williams has played as well as could’ve been expected, rushing for 226 yards and three touchdowns on 42 attempts. But Williams will miss Sunday’s game against the Tennessee Titans, as well, with a concussion.

Marshawn Lynch

Week 4 marked the first time since 2011 that the running back missed a game, and he’ll be a game-time decision for Sunday in Cincinnati. Lynch was a limited participant in Thursday’s practice, and Pete Carroll told KIRO Radio 97.3 FM's Dori Monson that his star rusher is “really close.” Thomas Rawls got the majority of Seattle’s carries in Lynch’s absence, totaling just 48 yards on 17 attempts. In the previous week, he rushed for 104 yards when Lynch only got the ball five times.

Alshon Jeffery

The Chicago Bears’ wide receiver caught five passes for 78 yards in the season opener, but he hasn’t played since. A hamstring injury has kept him sidelined for three straight games, and it could force him to sit out against the Kansas City Chiefs on Sunday. Jeffery wasn’t a full participant in Thursday’s practice. Eddie Royal, who leads the team’s wide receivers with 18 catches, has missed two straight days of practice with an ankle injury.

Victor Cruz

Cruz’s injured calf continues to delay his season debut. He’s been ruled out of the New York Giants’ game with the San Francisco 49ers on Sunday night. The wide receiver is set to meet with doctors this week to reevaluate his injury, and Cruz says he’s currently “day-to-day.” With Cruz sidelined, Rueben Randle is New York’s No.2 receiver, behind Odell Beckham Jr.

Sean Lee

It looked like the Cowboys might be without their top linebacker after he suffered a concussion against the New Orleans Saints in Week 4. But he’s been cleared to play against the New England Patriots in Week 5, and he'll be joined by linebacker Rolando McClain and defensive end Greg Hardy, who’ll make their season debuts.