The New Orleans Saints upset the Atlanta Falcons to start off Week 6 on “Thursday Night Football,” winning despite entering the contest as 3.5-point underdogs. The betting line for that game remained unchanged for most of the week, but a few point spreads have seen significant shifts in the last few days.

In a rematch of last year’s AFC Championship Game, the New England Patriots were favored over the Indianapolis Colts by 7.5 points on Tuesday. But just 48 hours later, the odds moved to make the visiting Patriots 10-point favorites. Quarterback Andrew Luck continues to practice, but there’s a chance he won’t play on Sunday night. New England continues to dominate their opponents, and the betting public seems to think they will make Indianapolis pay for their role in Deflategate.

The Green Bay Packers remain the biggest favorites of the week. The betting line in their game with the San Diego Chargers has gone from 9.5 points to 10.5 points.

The second-biggest shift has come in maybe the worst game of Week 6. The Houston Texans were favored by 1.5 points over the Jacksonville Jaguars on Wednesday, but the visiting Texans are now underdogs. Jacksonville is a one-point favorite, entering unfamiliar territory. Before Week 6, the Jaguars had been favored just once by Las Vegas sportsbooks in their last 48 games. Jacksonville is the victim of the worst loss this season, falling to the Patriots by 34 points in Week 3.

Coming off a bye week with a new head coach, the betting public is siding with the Miami Dolphins. They have gone from 2.5-point underdogs to getting 1.5 points in their visit to the Tennessee Titans.

Tyrod Taylor is apparently worth one point to the Buffalo Bills over EJ Manuel. With the news that the Bills starting quarterback won’t play, the point spread in their game with the Cincinnati Bengals has gone from 2.5 points to 3.5 points.

Below are updated betting lines for all the Week 6 games ahead of the weekend. These are the consensus odds from multiple sportsbooks in Las Vegas, via

Denver Broncos (-4) at Cleveland Browns, 42.5

Cincinnati Bengals (-3.5) at Buffalo Bills, 42.5

Kansas City Chiefs (+3.5) at Minnesota Vikings, 43.5

Houston Texans (+1) at Jacksonville Jaguars, 43

Chicago Bears (+3) at Detroit Lions, 43.5

Washington Redskins (+6) at New York Jets, 40.5

Arizona Cardinals (-3.5) at Pittsburgh Steelers, 44.5

Miami Dolphins (+1.5) at Tennessee Titans, 43.5

Carolina Panthers (+7) at Seattle Seahawks, 40.5

San Diego Chargers (+10.5) at Green Bay Packers, 50.5

Baltimore Ravens (-2) at San Francisco 49ers, 44

New England Patriots (10) at Indianapolis Colts, 54.5

New York Giants (+4) at Philadelphia Eagles, 49