NFL Week 6 Picks Against The Spread 2022: Predictions ATS, Odds, Schedule

Half of the games on the NFL Week 6 schedule feature a road favorite. Three teams that have a 4-1 record are underdogs. The Atlanta Falcons, Los Angeles Chargers, New York Giants and Dallas Cowboys have the best records against the spread in the 2022 season.

Here are picks against the spread for every game in Week 6 and updated betting odds from FanDuel and DraftKings Sportsbook.

Washington Commanders (+1) at Chicago Bears

Since beating Jacksonville in the opener, Washington has been the worst team in football. The Commanders have lost four consecutive games straight up and against the spread. Washington is averaging 15.5 points per game over that span. The last three road teams on "Thursday Night Football" have failed to score more than 17 points.

Prediction ATS: Chicago

Tampa Bay Buccaneers (-8.5) at Pittsburgh Steelers

The Steelers are going to lose a lot of games by double digits this season. Kenny Pickett's 61.5 passer rating would be the worst in the league if he played enough games to qualify among the leaders. The Buccaneers have given up 10.5 points per game when they haven't faced Patrick Mahomes and the Chiefs.

Prediction ATS: Tampa Bay

Jacksonville Jaguars (+2.5) at Indianapolis Colts

The Jaguars thoroughly dominated the Colts in a 24-0 victory just a few weeks ago. Indianapolis was fortunate to upset Kansas City and Denver, taking advantage of miscues. The Colts haven't scored more than 20 points in any game. Trevor Lawrence is probably a better quarterback than Matt Ryan at this point in their careers.

Prediction ATS: Jacksonville

Cincinnati Bengals (-1.5) at New Orleans Saints

The Saints won't have a better offensive game all season than they did in last week's 39-32 win over the Seahawks. Taysom Hill ran for 112 yards on nine carries with three touchdowns. The Bengals held Lamar Jackson in check, limiting him to 58 rushing yards, in a 19-17 defeat.

Prediction ATS: Cincinnati

New York Jets (+7) at Green Bay Packers

Green Bay's struggles in the passing game could limit the comfortable wins the team is able to secure this season. The Packers have only one victory by more than three points, and they haven't scored more than 27 points in any game. New York has exceeded expectations with its 3-2 start.

Prediction ATS: New York

New England Patriots (+3) at Cleveland Browns

New England's defense has played well outside of its Week 3 loss against Baltimore. The Patriots nearly won at Lambeau Field two weeks ago, and they might be able to pull off the upset in Cleveland. Jacoby Brissett has thrown three fourth-quarter interceptions that have cost the Browns.

Prediction ATS: New England

Minnesota Vikings (-3) at Miami Dolphins

It's hard to feel strongly about either side because of the Dolphins' uncertainty at quarterback. The Vikings have played with fire by barely escaping with victories over the Saints and Bears. Minnesota might finally get burnt in Miami.

Prediction ATS: Miami

Baltimore Ravens (-5) at New York Giants

Considering New York's 4-1 start, this point spread should probably be closer to a field goal. The Ravens nearly blew a third double-digit lead last week, needing a last-second field goal to hold off the Bengals. The Giants have the NFL's second-best rushing offense.

Prediction ATS: New York

San Francisco 49ers (-5.5) at Atlanta Falcons

The Falcons are going to have trouble getting anything going offensively. San Francisco has given up the fewest total yards and yards per play. Marcus Mariota hasn't thrown for 230 yards in any game.

Prediction ATS: San Francisco

Carolina Panthers (+10.5) vs. Los Angeles Rams

The Rams should absolutely beat the 1-4 Panthers, but it's hard to pick Los Angeles as a double-digit favorite when they've lost three games by at least 12 points. Maybe the Panthers will get a boost as a result of making changes at both head coach and quarterback. P.J. Walker can't play any worse than Baker Mayfield, who is injured after posting the league's worst passer rating.

Prediction ATS: Carolina

Arizona Cardinals (-2.5) at Seattle Seahawks

The Cardinals are 2-0 against the easiest part of their schedule and 0-3 against playoff contenders. Seattle's defense will likely keep it out of the postseason picture. The Seahawks are giving up the most yards per play.

Prediction ATS: Arizona

Buffalo Bills (-2.5) at Kansas City Chiefs

This might be the last time in a few years that Mahomes and the Chiefs are home underdogs. Kansas City defeated Buffalo 42-36 when the teams met in last season's playoffs. Expect another shootout that is decided on the last possession.

Prediction ATS: Kansas City

Dallas Cowboys (+4.5) at Philadelphia Eagles

The Cowboys have won four straight games in large part because of a dominant pass rush. Philadelphia is one of the few teams that can hold up well against Dallas because of its offensive line and Jalen Hurts' mobility. Discounting defensive scores, the Eagles have given up 11.0 offensive points per game over the last four weeks. The Cowboys are 24th in scoring.

Prediction ATS: Philadelphia

Denver Broncos (+4.5) at Los Angeles Chargers

Unless the procedure that Russell Wilson recently underwent on his throwing shoulder significantly improves his play, the Broncos will have a hard time winning in Los Angeles. Denver hasn't scored 24 points in any game. The Chargers have scored at least 24 points in four of five contests.

Prediction ATS: Los Angeles

Season Record: 37-41-2