It's the classic David vs. Goliath matchup.
Ohio State has made 10 Final Fours in school history. This is just Loyola's second trip to the NCAA Tournament.
15th seeded Loyola will try to upset the number two Buckeyes, as the teams get underway in Pittsburgh at approximately 9:50 p.m. ET.
The game will be broadcast on TNT.
If you can't get to a television, the game can be seen online.
March Madness On Demand allows you to watch every game of the NCAA Tournament on your computer, iPhone, iPad and select Android phone for a one-time payment of $3.99
The Buckeyes have been one of the nation's best teams all season long, and could have been a one seed if they had beaten Michigan State in the Big 10 Championship Game.
Loyola received an automatic bid after winning the MAAC Tournament. The Greyhounds won 24 games during the season and finished 13-5 in their conference. Ohio State won 27 games on the year.
Ohio State is led by sophomore big man Jared Sullinger. He averages 17.6 points and 9.3 rebounds per game. The Greyhounds have a balanced scoring attack, with five different players averaging at least nine points per contest.
Ohio State comes into the game as 17-point favorites.
The winner of this game will take on the victor of the Gonzaga-West Virginia matchup.