The Oprah Winfrey Show, the American syndicated talk show, hosted and produced by Oprah Winfrey herself, has been the highest-rated talk show in American television history.

The show has been highly discussed and many of its topics go deep into American pop-cultural consciousness.

It has been one of the longest-running daytime television talk shows in the United States history, airing since September 8, 1986, which consists of over 24 seasons and 4,000 episodes. The show's last episode will air on May 25, 2011.

Below are some of the show's distinguished guests: