Gunning for their first Sweet 16 appearance since 2007, the No. 12 Oregon Ducks square off against the favored No.4 Saint Louis Billikens Saturday in the third round of the NCAA Tournament in San Jose.

When the seeds and regions were first announced, many pegged the Ducks as under-rated or disrespected by the selection committee, but it might have given them the edge they needed in their 68-55 win over Oklahoma State in the second round.

Freshman guard Damyean Dotson led all scorers with 17 points, and Arsalan Kazemi single-handedly dominated the boards with a whopping 17 rebounds to go along with his 11 points.

Dominic Artis netted 13 points, and Carlos Emory came off the bench for 12 points, and the Ducks overcame a poor 39 percent shooting night and 18 turnovers by crashing the offensive glass for 14 boards.

Season leading scorer E.J. Singler had a rough overall game, going 3-for-12 from the field and generating four turnovers.

A huge rebounding discrepancy may not be enough to put away Saint Louis. The Billikens gave up 21 offensive rebounds, but still managed a 64-44 blowout win over New Mexico State.

Junior Dwayne Evans scored 24 points with six rebounds, and Saint Louis held the Aggies' offense in check, giving up a shade under 28 percent shooting, and a suffocating 2-for-16 along the three point line.

Senior forwards Cody Ellis and Cory Remekun recorded 23 combined points, with Ellis shooting 3-for-4 from beyond the arc in the Billikens fifth all-time tournament victory.

The Billikens have never made it out of the tournament’s first weekend.

The game tips-off at 7:10 p.m. Eastern and will be broadcast by TBS, or watch a free live online stream at the NCAA March Madness official site here.

Betting Odds: St. Louis is favored by 4 points.

Over/Under: 124 points

Prediction: Saint Louis will have to do a much better job on the boards than in its last game. The Ducks will pound them inside, and have strong enough guard play to possibly even overwhelm the Billikens. Look for Oregon to squeeze out a win with a late second half surge.

Predicted Score: Oregon 61, St. Louis 55