When and Where: The La Liga Match kicks-off from Pamploma at 2 p.m. ET. A live stream will be available on ESPN3.
Preview: Real Madrid will be looking to maintain their advantage over Barcelona in the race for the La Liga title but will not find it easy against an Osasuna side fighting for a Champions League place.
Real currently hold a six point lead over their historic rivals and will be eager to make that nine before Barcelona take to the pitch immediately following the completion of this match.
Los Blancos took a giant step toward the semi-finals of the Champions League during the week with a 3-0 win over Apoel Nicosia in the first leg of their tie.
With the return match surely nothing but a formality on Wednesday, Mourinho should be able to field a full-strength, fully-focused team in Pamploma.
But Osasuna have everything to play for themselves. Los Rojillos currently sit in an impressive sixth spot in the standings and lie just four points behind Valencia and Malaga in third and fourth, respectively.
Osasuna will also have the added motivation of wanting to give a better account of themselves than they did in the reverse meeting at the Bernabeu earlier in the season. On that occasion Real were on fire, winning 7-1, with a hat-trick from Cristiano Ronaldo.
Team News: Right-back Marc Bertran will miss out for Osasuna through injury, with Jukka Raitala, who replaced him in the 2-0 win over Levante likely to come in.
Up front, coach Jose Luis Mendilibar should keep faith with Nino following his goal last week, despite the return to fitness of Dejan Lekic.
Mesut Ozil returns from his domestic suspension, but, despite being eligible again, Lassana Diarra is injured. Also ruled out though injury is Ricardo Carvalho and Sami Khedira. Xabi Alonso is free to return after his European suspension.
Confirmed Real XI: Casillas, Arbeloa, Ramos, Albiol, Marcelo, Xabi Alonso, Granero, Ronaldo, Ozil, Benzema, Higuain.
Prediction: Osasuna should certainly fair better than earlier in the season, but it is still a tough ask for them to halt the progress of Real, even given their impressive home record.
Despite the absence of Pepe and Carvalho, Osasuna may struggle to take advantage, as they have struggled for goals throughout the campaign.
Osasuna 0-2 Real Madrid