The top after-market NASDAQ gainers Wednesday were: MannKind Corp, Seanergy Maritime Holdings, Savient Pharmaceuticals, Star Scientific, AVEO Pharmaceuticals and NewLead Holdings. The top after-market NASDAQ losers were: Avid Technology, Apogee Enterprises, Zix Corp, Approach Resources, Bruker Corp and Pacira Pharmaceuticals.

Gainers

MannKind Corp. (MNKD) stock surged 4.41 percent to $2.25 in post market session.

Seanergy Maritime Holdings Corp. (SHIP) stock surged 4.23 percent to $3.94 in post market session. The company stock climbed nearly 20 percent in regular session.

Savient Pharmaceuticals Inc. (SVNT) stock surged 3.38 percent to $2.14 in post market session after surging more than 5 percent in regular trade.

Star Scientific, Inc. (CIGX) stock gained 3.24 percent to $3.19 in post market session. The company stock surged more than 11 percent in regular trade on news that it has received a patient for a method of curing tobacco comprises drying a harvested tobacco plant in a controlled environment for a time sufficient to substantially prevent the formation of at least one nitrosamine.

AVEO Pharmaceuticals, Inc. (AVEO) stock gained 3.12 percent to $11.25 in post market session. The company stock declined more than 3 percent in regular session.

NewLead Holdings Ltd. (NEWL) stock gained 2.68 percent to $4.59 in post market session. The company stock climbed 79 percent in regular session. Last week, the company announced further progress in the restructuring process with the redelivery of four dry bulk vessels.

Losers

Avid Technology, Inc. (AVID) stock slumped 15.37 percent to $8.70 in aftermarket session. The company currently expects first quarter revenues to be approximately $152 million, missed analysts' estimation of $161.08 million, hurt by weaker demand in its creative enthusiast segment.

Apogee Enterprises, Inc. (APOG) stock slumped 7.93 percent to $12.65 in post market session. The company swung to fourth quarter net profit of $2.96 million or $0.11 per share compared to net loss of $4.41 million or $0.16 per share in the same period last year. The company also expects fiscal 2013 net income to in a range of $0.40 to $0.50 per share, but fell short of analysts' estimation of $0.59 per share.

Zix Corp. (ZIXI) stock plunged 4.93 percent to $2.70 in post market session.

Approach Resources Inc. (AREX) stock declined 1.71 percent to $34.40 in post market session. The stock has a 52-week low of $14.14, a 52-week high of $39.18 and $1.17 billion in market capitalization.

Bruker Corp. (BRKR) stock fell 1.68 percent to $14.19 in post market session. The stock has a 52-week low of $11.48, a 52-week high of $21.44 and $2.39 billion in market capitalization.

Pacira Pharmaceuticals, Inc. (PCRX) stock fell 1.68 percent to $9.95 in post market session. The company announced that it has commenced an underwritten public offering of shares of its common stock.