Manchester United are likely to start with Wayne Rooney, who was on the bench last week for the Liverpool game, while although captain Nemanja Vidic has regained enough fitness, it is unclear whether he will start his second game in five days.
United are still without midfielder Tom Cleverley and defender Rafael.
City forward Mario Balotelli is set to make his return after missing the Champions League match during midweek through suspension. Former United man Owen Hargreaves will undergo a late fitness test.
Of the 159 matches between the two sides, United have won 66 times while City have 43 victories, with 50 draws.
Much depends on whether Roberto Mancini goes defensive. That could be the difference between a classic and a goalless draw. However, both teams have enough fire power to ensure goals.
United 1-1 City