After winning the division last year, the Indianapolis Colts have yet to take sole possession of first place in the 2014 NFL season. A win on “Thursday Night Football” in Week 6 against the Houston Texans would put the defending AFC South champs atop the division for the first time all year.

Andrew Luck looks to continue his success against Houston, whom he’s defeated in three out of four tries. Luck has thrown for nine touchdowns and just one interception in his career against the Texans, along with a 91.6 passer rating.

Houston is dealing with injuries to its top playmakers. Andre Johnson is listed as questionable and it’s uncertain if he’ll be ready to play. An ankle injury has kept him out of practice this week, though he was questionable in Week 5 and still managed to suit up. In five games, the veteran has yet to surpass the 100-yard mark or find his way into the end zone.

Arian Foster has been dealing with an injury for much of the year, and he’s listed as probable on the injury report. He’ll likely be on the field, following his 157-yard performance on 23 carries in Week 5. Running back Alfred Blue is also probable, having sat out Monday’s practice but participating on Wednesday.

Indianapolis will be without both of their starting guards against Houston. Jack Mewhort and Hugh Thornton won’t be able to protect Luck against J.J Watt and the Texans defensive line because of injuries. Watt was named the AFC Defensive Player of the Month for September, recording two sacks and returning an interception for a touchdown.

NFL fans continue to tune in to “Thursday Night Football,” even though the all of the games in 2014 have been blowouts. The Week 6 contest might have a better chance than any of the previous games of being competitive, considering the three-point betting line is tied for the smallest on Thursday night this year.

Start Time: 8:25 p.m. ET

Point Spread: Colts by eight points

Over/Under: 46.5 points

TV Channel: CBS and NFL Network will have a simulcast

Live Online Stream: A live online stream is available at NFL Network here

Prediction: Indianapolis 31, Houston 17