The top pre-market NASDAQ stock market losers are Sinovac Biotech, Quidel Corp, The Wet Seal, Mindspeed Technologies, Celldex Therapeutics, Leap Wireless and Research in Motion.

Sinovac Biotech, Ltd. (NASDAQ:SVA) shares declined 12.30 percent to $3.7 in pre-market trading session on Thursday. The company expects its fourth quarter sales to be in the range of around $7.8 million to $10.8 million. Its full year sales are expected to be in the range of $32 million to $35 million against market expectation of $42.34 million.

Quidel Corp (NASDAQ:QDEL) shares declined 8.52 percent to $13.20 in pre-market trading session. The company reported lower-than-expected fourth quarter revenue guidance citing a significant decline in sales of its influenza products.

The Wet Seal, Inc. (NASDAQ:WTSLA) shares declined 7.93 percent to $3.60 in pre-market trading session. Its December same store sales declined 2.1 percent%, reflecting pressure on merchandise margin at its Wet Seal division.

Mindspeed Technologies, Inc. (NASDAQ:MSPD) shares declined 6.15 percent to $6.10 in the pre-market trading session. The company cut its first quarter revenue guidance that came in below analysts’ forecast. The company cited a weaker demand environment in the first quarter of 2011.

Celldex Therapeutics, Inc. (NASDAQ:CLDX) shares declined 4.31 percent to $4.0 in pre-market trading session.

Leap Wireless International, Inc. (NASDAQ:LEAP) shares declined 2.30 percent to $13.70 pre-market trading session.

Research in Motion Ltd (NASDAQ:RIMM) shares declined 1.73 percent to $60.85 in pre-market trading session.

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