Michael Bisping Georges St-Pierre
UFC president Dana White stands in-between Georges St-Pierre and defending middleweight UFC champion Michael Bisping during the NHL game between the Montreal Canadiens and the Toronto Maple Leafs at the Bell Centre on Oct. 14, 2017 in Montreal, Quebec, Canada. Bisping will fight St-Pierre in the main event of UFC 217. Minas Panagiotakis/Getty Images

One of the greatest MMA fighters returns to the octagon four years after his last fight in the main event of UFC 217. Georges St-Pierre will challenge Michael Bisping for the UFC middleweight championship Saturday night at Madison Square Garden.

If the betting odds are any indication, the title fight is too close to call. St-Pierre is the slightest of favorites, via Bovada.lv, though the bout is essentially a toss-up. Bisping will fight for the first time since he successfully defended the belt against Dan Henderson on Oct. 8, 2016 at UFC 204.

The championship fights beyond the bout between Bisping and St-Pierre make this one of the biggest events in UFC history. UFC president Dana White said Thursday that the event will provide MSG with its third-largest gate in the building’s existence. UFC 205, which saw Conor McGregor win the UFC lightweight championship a year ago, stands at No.1.

Cody Garbrandt will defend his UFC bantamweight championship for the first time when he faces T.J. Dillashaw Saturday night. Garbrandt is the only male UFC champion that has no losses on his resume.

Joanna Jedrzejczyk has never lost a fight as a pro, and that’s expected to remain the same when she puts her strawweight title on the line against Rose Namajunas. Jedrzejczyk’s last four title defenses have all gone the distance.

UFC 217 starts on pay-per-view at 10 p.m. EDT, and fans can buy it for $69.99. The preliminary card begins at 8 p.m. EDT on Fox Sports 1.

Main Card

Middleweight Title: Michael Bisping (-110) vs. Georges St-Pierre (-120)

Bantamweight Title: Cody Garbrandt (-185) vs. T.J. Dillashaw (+150)

Women's Strawweight Title: Joanna Jedrzejczyk (-600) vs. Rose Namajunas (+400)

Welterweight: Stephen Thompson (-190) vs. Jorge Masvidal (+155)

Middleweight: Johny Hendricks (+215) vs. Paulo Costa (-275)

FS1 Prelims

Lightweight: James Vick (+135) vs. Joseph Duffy (-165)

Heavyweight: Walt Harris (-380) vs. Mark Godbeer (+290)

Light Heavyweight: Ovince Saint Preux (-165) vs. Corey Anderson (+135)

Welterweight: Randy Brown (-110) vs. Mickey Gall (-120)

UFC Fight Pass Prelims

Heavyweight: Oleksiy Oliynyk (+270) vs. Curtis Blaydes (-360)

Light Heavyweight: Ion Cuțelaba (-500) vs. Michał Oleksiejczuk (+350)

Bantamweight: Aiemann Zahabi (+160) vs. Ricardo Ramos (-200)