The Denver Broncos (6-6) have one of the easiest remaining schedules of any fringe playoff team, but a series of unfortunate, late-season injuries might derail their chances. The Broncos published a lengthy injury report ahead of their Week 14 matchup with the lowly San Francisco 49ers (2-10).

Defensive contributors Shaquil Barrett (hip), Tramaine Brock (ribs), Chris Harris Jr. (leg) and Derek Wolfe (ribs) did not practice Wednesday. Emmanuel Sanders, the team’s best receiver, was limited in practice, but only because he tore his Achilles on a non-contact play during the session.

Brandon Marshall (knee) was also limited, while rookies Courtland Sutton (ankle) and Josey Jewell (ankle) were full participants.

Sanders is out for the rest of the year, while Harris will likely miss at least most of the rest of the regular season. After starting 3-6, the Broncos have won three games in a row and put themselves in a good position to finish 9-7 or 10-6.

Their next three opponents have combined records of 8-27-1. Their last game is a home contest against the Los Angeles Chargers (9-3), who the Broncos already beat on the road during this current winning streak.