Thursday night’s last-second home loss to the Los Angeles Chargers (11-3) could have devastating ramifications for the Kansas City Chiefs (11-3). Aside from needing to put more work in to win the AFC West and get the conference’s top seed, the Chiefs’ secondary will lose one of its better players to injury.

Cornerback Kendall Fuller, who was the centerpiece of the trade that sent quarterback Alex Smith to Washington, apparently played through a wrist injury on Thursday and will need surgery. NFL insider Ian Rapoport’s sources called it a fracture.

Fuller was one of the better starters in a secondary that allows the most passing yards per game in the NFL. Pro Football Focus ranked him as the 20th best cornerback in the league this year. He had a big interception of an errant Philip Rivers pass at the end of the first half, but was flagged for pass interference on third down on the Chargers’ game-winning drive.

It is not yet known how long Fuller will be out. In his absence, the Chiefs might have to turn to veteran Orlando Scandrick or rookies Charvarius Ward or Tremon Smith.