The 2012 NFL Season opens up on Wednesday, Sept. 5 at MetLife Stadium. The defending Super Bowl champion New York Giants are set to host their division rival Dallas Cowboys.

The rest of the league will make their debuts on Sunday, with two games scheduled for Monday.

The Texans are considered one of the favorites to win the title this year, and they are the biggest favorites this week. Houston is a 12.5-point favorite over rookie Ryan Tannehill and the Miami Dolphins. The Colts are the biggest home underdogs. The worst team in the NFL in 2011 is getting 9.5 points as Indianapolis faces Chicago.

Below are the complete betting lines for all the Week 1 games, including the point spreads and totals. These are the consensus odds from multiple sportsbooks in Las Vegas.


Dallas (+3.5) at NY Giants, 45


Chicago (-9.5) at Indianapolis, 43.5

Philadelphia (-8.5) at Cleveland, 43.5

Buffalo (+3) at NY Jets, 38.5

Washington (+7) at New Orleans, 50

New England (-5.5) at Tennessee, 47

Jacksonville (+3.5) at Minnesota, 38.5

Miami (+12.5) at Houston, 43

St. Louis (+7) at Detroit, 45.5

Atlanta (-3) at Kansas City, 43.5

San Francisco (+5) at Green Bay, 46.5

Carolina (-2.5) at Tampa Bay, 47

Seattle (-2.5) at Arizona, 40.5

Pittsburgh (+1.5) at Denver, 44.5


Cincinnati (+6) at Baltimore, 41

San Diego (+1) at Oakland, 47