Tom Brady hasn’t even played a game since his suspension ended, but his impact is already being felt. Upon his return, the New England Patriots are the biggest road favorites of the 2016 NFL season.

New England visits the Cleveland Browns in Week 5, facing the league’s only remaining winless team. The Browns have gone 0-4 with three different starting quarterbacks, and now they are 10-point underdogs at home. The Carolina Panthers were 14-point favorites against the visiting San Francisco 49ers in Week 2, but the Patriots would likely be giving the Browns 16 points if the game was being played in New England.

Only two other games on the Week 5 schedule feature a point spread of at least a touchdown. Both New York teams are seven-point underdogs as the Jets visit the Pittsburgh Steelers and the Giants face the Green Bay Packers on Sunday night. The Jets and Giants are coming off back-to-back losses, and both teams were beaten by two scores in Week 4.

The matchup between the Cincinnati Bengals and Dallas Cowboys features the smallest point spread on the schedule. Even though Cincinnati has one fewer win than Dallas, the Bengals are one-point road favorites.

No point spread has been set for the game on “Monday Night Football.” The Carolina Panthers opened as six-point favorites against the Tampa Bay Buccaneers, but the betting line has been taken off the board at sportsbooks because of the injury to Cam Newton. After the quarterback suffered a concussion against the Atlanta Falcons in Week 4, it’s unknown if he’ll be able to play in Week 5.

The contest between the Houston Texans and Minnesota Vikings features the lowest over/under of the week at 40. The San Diego Chargers and Oakland Raiders are expected to have the highest-scoring game.

The Kansas City Chiefs, New Orleans Saints, Seattle Seahawks and Jacksonville Jaguars all have byes in Week 5.

Below are the complete betting lines for all the Week 5 games, including the point spreads and totals. These are the consensus odds from multiple sportsbooks in Las Vegas and online, via OddsShark.

Arizona Cardinals (-3) at San Francisco 49ers, 42.5

Houston Texans (+5.5) at Minnesota Vikings, 39.5

Tennessee Titans (+3.5) at Miami Dolphins, 43.5

New England Patriots (-10) at Cleveland Browns, 46.5

New York Jets (+7) at Pittsburgh Steelers, 48.5

Washington Redskins (+3.5) at Baltimore Ravens, 46.5

Philadelphia Eagles (-3) at Detroit Lions, 46

Chicago Bears (+4.5) at Indianapolis Colts, 47.5

Atlanta Falcons (+6) at Denver Broncos, 47

Buffalo Bills (+3) at Los Angeles Rams, 40

San Diego Chargers (+4) at Oakland Raiders, 50

Cincinnati Bengals (-1) at Dallas Cowboys, 45.5

New York Giants (+7) at Green Bay Packers, 48.5

Tampa Bay Buccaneers (N/A) at Carolina Panthers, N/A