Some of the NFL’s best teams are expected to win big Sunday, according to the Week 10 betting odds. Four teams are favored by at least nine points, including one that plays on the road.

The game between the Los Angeles Rams and Houston Texans features the week’s biggest betting line. Without Deshaun Watson, Houston is an 11.5-point underdog in L.A. The point spread likely would’ve been close to a field goal if the Texans weren’t forced to start Tom Savage at quarterback.

Coming off their bye week, the Pittsburgh Steelers will go on the road to face the Indianapolis Colts. The AFC North leaders are laying double-digits against Jacoby Brissett and Co. Pittsburgh is on a three-game winning streak.

The Detroit Lions are nearly 10-point favorites against the winless Cleveland Browns. The 6-3 Carolina Panthers are favored by nine points over the visiting Miami Dolphins.

The New York Giants and San Francisco 49ers will face off in easily the worst game of Week 10. The betting line is a pick’em for the contest that features two teams that have one combined victory.

Five teams in total are favored on the road, including the Steelers, New England Patriots and New Orleans Saints. All three of those teams would have a bye if the playoffs started in Week 10. The Minnesota Vikings, who are the No.3 seed in the NFC, are also favored on the road.

The Baltimore Ravens, Kansas City Chiefs, Oakland Raiders and Philadelphia Eagles all have a bye in Week 10.

Below are the complete betting lines for all the Week 10 games, including the point spreads and totals. These are the consensus odds from multiple sportsbooks in Las Vegas and online, via OddsShark.


Seattle Seahawks (-5.5) at Arizona Cardinals, 41.5


New York Jets (+1.5) at Tampa Bay Buccaneers, 42

Pittsburgh Steelers (-10.5) at Indianapolis Colts, 44.5

New Orleans Saints (-2) at Buffalo Bills, 46

Green Bay Packers (+3) at Chicago Bears, 41

Minnesota Vikings (-1) at Washington Redskins, 42.5

Los Angeles Chargers (+4) at Jacksonville Jaguars, 41

Cleveland Browns (+9.5) at Detroit Lions, 41

Cincinnati Bengals (+5) at Tennessee Titans, 40.5

Houston Texans (+11.5) at Los Angeles Rams, 46.5

Dallas Cowboys (+3) at Atlanta Falcons, 50.5

New York Giants (PK) at San Francisco 49ers, 41.5

New England Patriots (-7.5) at Denver Broncos, 46.5


Miami Dolphins (+9) at Carolina Panthers, 39.5