Week 3 of the 2019 NFL season features one of the most unique schedules in league history. Two teams find themselves favored by more than three touchdowns, and a few betting lines have seen major changes because of quarterback injuries.

The Dallas Cowboys are laying 21.5 points at home against the Miami Dolphins, who have been outscored by 92 points in their first two games. With both Sam Darnold and backup quarterback Trevor Siemian potentially out for Week 3, the New York Jets are 21.5-point underdogs in their road matchup with the New England Patriots.

Four other teams are favored by at least a touchdown at home. The 2-0 San Francisco 49ers are laying seven points against the visiting Pittsburgh Steelers now that Ben Roethlisberger is done for the year. The Philadelphia Eagles are seven-point favorites against the undefeated Detroit Lions.

The New Orleans Saints were likely to be road favorites against the Seattle Seahawks. Drew Brees is expected to miss at least six weeks with a thumb injury. Teddy Bridgewater and the Saints are now getting five points in Seattle.

The Baltimore Ravens are the only team that’s an underdog after winning their first two games. They are getting 6.5 points in Kansas City. With Lamar Jackson and Patrick Mahomes playing like very early MVP candidates, the contest features the week’s highest over/under.

Four road teams are favored in Week 3. Three of those favorites will play in primetime.

The Los Angeles Rams are laying 2.5 points in Cleveland on “Sunday Night Football.” The Washington Redskins are four-point underdogs at home against the Chicago Bears on “Monday Night Football.”

The Tennessee Titans kick off the schedule as small road favorites in Jacksonville. Thursday night’s game has the lowest total in Week 3.

Dak Prescott Dallas Cowboys
Dak Prescott #4 of the Dallas Cowboys hands the ball off to Ezekiel Elliott #21 of the Dallas Cowboys against the Tampa Bay Buccaneers in the fourth quarter at AT&T Stadium on December 23, 2018 in Arlington, Texas. Tom Pennington/Getty Images

Below are the complete betting lines for all the Week 3 games, including the point spreads and totals. These are the consensus odds from multiple sportsbooks in Las Vegas and online, via OddsShark.

Thursday, Sept. 19

Tennessee Titans (-1.5) at Jacksonville Jaguars, 40

Sunday, Sept. 22

Miami Dolphins (+21.5) at Dallas Cowboys, 47.5

Denver Broncos (+7.5) at Green Bay Packers, 43

Baltimore Ravens (+6.5) at Kansas City Chiefs, 55

Oakland Raiders (+8) at Minnesota Vikings, 42.5

Cincinnati Bengals (+6) at Buffalo Bills, 44

Atlanta Falcons (+2.5) at Indianapolis Colts, 47

New York Jets (+21.5) at New England Patriots, 46

Detroit Lions (+7) at Philadelphia Eagles, 48

Carolina Panthers (-2.5) at Arizona Cardinals, 46.5

New York Giants (+6.5) at Tampa Bay Buccaneers, 48

Houston Texans (+3) at Los Angeles Chargers, 48

New Orleans Saints (+5) at Seattle Seahawks, 44.5

Pittsburgh Steelers (+7) at San Francisco 49ers, 43.5

Los Angeles Rams (-2.5) at Cleveland Browns, 51

Monday, Sept. 23

Chicago Bears (-4) at Washington Redskins, 41.5