Some of the NFL’s top contenders are underdogs for Week 11. The Arizona Cardinals, Dallas Cowboys and New Orleans Saints are not favored in their matchups, according to the opening betting odds.

Dallas visits the Kansas City Chiefs in the marquee Week 11 matchup. The betting line favors the Chiefs by 2.5 points, despite Patrick Mahomes and Kansas City continuing to struggle. With a betting total of 52.5, the game is projected to be the highest-scoring affair on the schedule.

Arizona is getting a point in their road matchup with the Seattle Seahawks. Russell Wilson's return makes Seattle a viable playoff contender, once again. The Cardinals have a sizable lead over the Seahawks atop the NFC West.

The matchup between the Saints and Philadelphia Eagles is listed as a pick’em. New Orleans is ahead of Philadelphia in the NFC standings, though the Eagles probably have the better quarterback with Trevor Siemian becoming the Saints’ starter.

The biggest point spread comes on “Monday Night Football.” The Tampa Bay Buccaneers are laying 12 points against the visiting New York Giants. The Giants were competitive against the Bucs last year in a Monday night matchup, coming up just short against the Super Bowl champs in a 25-23 loss.

The New England Patriots are favored over the Atlanta Falcons on “Thursday Night Football.” The Pittsburgh Steelers are underdogs in their Sunday night matchup with the Los Angeles Chargers.

The Cleveland Brown and Tennessee Titans are both favored by double digits. The Buffalo Bills are laying a touchdown.

The Green Bay Packers are short road favorites in a key NFC North matchup with the Minnesota Vikings. A win for Green Bay could all but lock up the division championship.

The Denver Broncos and Los Angeles Rams have a bye in Week 11. The betting line for a couple of games isn’t yet available.

Here are the opening betting lines for the games in Week 11 of the 2021 NFL season, including the point spreads and totals, via DraftKings Sportsbook.

Thursday, Nov. 18

New England Patriots (-4) at Atlanta Falcons, 46

Sunday, Nov. 21

New Orleans Saints (PK) at Philadelphia Eagles, 43.5

Green Bay Packers (-2) at Minnesota Vikings, 50.5

Washington Football Team (+1.5) at Carolina Panthers, 43

Indianapolis Colts (+6.5) at Buffalo Bills, 50

Detroit Lions (+10) at Cleveland Browns, 46.5

San Francisco 49ers (-5.5) at Jacksonville Jaguars, 47

Houston Texans (+10) at Tennessee Titans, 46.5

Cincinnati Bengals (PK) at Las Vegas Raiders, 48.5

Arizona Cardinals (+1) at Seattle Seahawks, 50.5

Dallas Cowboys (+2.5) at Kansas City Chiefs, 52.5

Pittsburgh Steelers (+3.5) at Los Angeles Chargers, 48.5

Miami Dolphins (N/A) at New York Jets 

Baltimore Ravens (N/A) at Chicago Bears 

Monday, Nov. 22

New York Giants (+12) at Tampa Bay Buccaneers, 51

Shaq Barrett Patrick Mahomes Chiefs Buccaneers Patrick Mahomes #15 of the Kansas City Chiefs looks to pass against Shaquil Barrett #58 of the Tampa Bay Buccaneers in Super Bowl LV at Raymond James Stadium on February 07, 2021 in Tampa, Florida. Photo: Patrick Smith/Getty Images