For the first time in the 2021 NFL season, there are games scheduled on four days during the same week. Two Saturday games with playoff implications and a loaded Sunday slate are set for Week 15.

The Week 15 action starts with an important AFC West matchup between the Kansas City Chiefs and Los Angeles Chargers. The Chiefs are three-point favorites on the road. Los Angeles upset Kansas City earlier this season.

The Las Vegas Raiders visit the Cleveland Browns in the first Saturday game of the season. The loser could have a difficult time climbing back into the playoff race.

The New England Patriots open as short road favorites against the Indianapolis Colts in Saturday’s primetime matchup. New England is the AFC’s No. 1 seed with a seven-game winning streak.

The Green Bay Packers visit the Baltimore Ravens in Sunday’s biggest game. Both teams are in contention to earn a first-round playoff bye.

The Arizona Cardinals have opened as the biggest Week 15 favorites, laying 12.5 points against the Detroit Lions. The Tampa Bay Buccaneers are favored by 11.5 points over the New Orleans Saints Sunday night. The Saints upset the defending champs earlier this season.

There are a pair of NFC East matchups set for Sunday. The New York Giants are double-digit underdogs at home against the Dallas Cowboys. The Philadelphia Eagles are short favorites against the Washington Football Team in a battle of playoff contenders.

The Pittsburgh Steelers are essentially in a must-win situation when they host the Tennessee Titans. Pittsburgh's playoff chances took a major hit with its Week 14 loss.

The Minnesota Vikings are given the edge over the Chicago Bears on “Monday Night Football.”

Here are the opening betting lines for the games in Week 15 of the 2021 NFL season, including the point spreads and totals, via DraftKings Sportsbook.

Thursday, Dec. 16

Kansas City Chiefs (-3) at Los Angeles Chargers, 49.5

Saturday, Dec. 18

Las Vegas Raiders (+5.5) at Cleveland Browns, 44

New England Patriots (-1) at Indianapolis Colts, 43.5

Sunday, Dec. 19

Dallas Cowboys (-10) at New York Giants, 45

Houston Texans (+3.5) at Jacksonville Jaguars, 43

Tennessee Titans (-2.5) at Pittsburgh Steelers, 43

Arizona Cardinals (-12.5) at Detroit Lions, 47.5

Carolina Panthers (+9.5) at Buffalo Bills, 45

New York Jets (+7) at Miami Dolphins, 44.5

Washington Football Team (+2.5) at Philadelphia Eagles, 44.5

Cincinnati Bengals (-3) at Denver Broncos, 44.5

Atlanta Falcons (+7.5) at San Francisco 49ers, 44.5

Green Bay Packers (-2) at Baltimore Ravens, 45.5

Seattle Seahawks (N/A) at Los Angeles Rams, 48

New Orleans Saints (+11.5) at Tampa Bay Buccaneers, 48

Monday, Dec. 20

Minnesota Vikings (-4) at Chicago Bears, 43.5

Mike Evans Tom Brady Buccaneers Fan
Mike Evans #13 of the Tampa Bay Buccaneers celebrates with fans after scoring a touchdown in the first quarter against the Chicago Bears in the game at Raymond James Stadium on October 24, 2021 in Tampa, Florida. Mike Ehrmann/Getty Images