There are several large betting lines in Week 10 with some of the NFL’s worst teams set to face Super Bowl contenders. Four teams are favored by at least 10 points, and four teams with losing records are home underdogs.

Below are picks against the spread for every game in Week 10, as well as updated betting odds at Las Vegas and online sportsbooks. Betting lines and trends are courtesy of OddsShark.

Seattle Seahawks (-5.5) at Arizona Cardinals

The Cardinals have gotten to .500 by beating up on bad teams. Their only victories have come against teams that will be picking near the top of the draft, and Arizona has lost by double-digits every time they’ve faced a playoff contender. Drew Stanton is in for a long night against the “Legion of Boom.” Seattle is 4-1 against the spread in their five games in Arizona.

Prediction ATS: Seattle

New York Jets (-2.5) at Tampa Bay Buccaneers

The Jets were the right pick when they started Week 10 as underdogs in Tampa Bay. That’s probably no longer the case now that they are favored by nearly a field goal on the road. Despite how awful Ryan Fitzpatrick was for New York a year ago, he’s been productive when playing for the injured Jameis Winston in 2017. Both of the Bucs’ wins have come at home, and they nearly beat the Patriots in Tampa Bay. The Jets are 1-2 on the road with their only victory coming against the winless Browns.

Prediction ATS: Tampa Bay

Pittsburgh Steelers (-10.5) at Indianapolis Colts

As good as the Steelers might be, it’s hard to lay more than 10 points on the road against a team that’s been competitive in most of their games with Jacoby Brissett at quarterback. The Colts were blown out at Seattle and at home against the Jaguars, but Indianapolis isn’t exactly a pushover. Pittsburgh has played down to their competition at times, beating Cleveland by just a field goal and losing to Chicago.

Prediction ATS: Indianapolis

New Orleans Saints (-3) at Buffalo Bills

It might be a good idea to keep picking New Orleans until they lose again. The Saints have gone unbeaten since Week 3, looking like a real Super Bowl contender. New Orleans has covered the spread five times during their winning streak. When they were nine-point favorites against the Bears, they won by eight points. Now that it’s clear Atlanta is no longer one of the league’s best teams, Buffalo still has to prove that they can beat elite competition.

Prediction ATS: New Orleans

Green Bay Packers (+5.5) at Chicago Bears

The value of Aaron Rodgers becomes more evident with each game that the Packers are forced to start another quarterback. Brett Hundley has been bad under center for Green Bay, and Mike McCarthy’s conservative play calling hasn’t helped matters. If the Bears have any success on offense with their two-headed monster at running back, Green Bay won’t be able to get back into the game.

Prediction ATS: Chicago

Minnesota Vikings (-1) at Washington Redskins

Let’s see what Case Keenum can do on the road against a team that actually has a chance to make the playoffs. Minnesota’s offense did nothing when Keenum started in Pittsburgh and at home against Detroit, scoring a combined 16 points. The same could happen against the Redskins, who are coming off an impressive win in Seattle.

Prediction ATS: Washington

Los Angeles Chargers (+4) at Jacksonville Jaguars

Jacksonville’s defense looks like it’s the NFL’s best. It should continue to look that way against a Chargers’ team that is tied for 22nd in scoring. Philip Rivers ranks 17th in passer rating, and he could throw a few interceptions against an elite secondary.

Prediction ATS: Jacksonville

Cleveland Browns (+13) at Detroit Lions

The Browns really might go 0-16 this year. They’ve been competitive a couple of times, but it hasn’t been the norm. Cleveland has lost by at least 14 points in four of their last seven games, and they are 0-4-1 against the spread in their last five road games. The Browns have scored more than 18 points just once, and the Lions are scoring 25 points per game at home.

Prediction ATS: Detroit

Cincinnati Bengals (+4.5) at Tennessee Titans

It’s hard to trust Tennessee’s offense at this point. Marcus Mariota hasn’t been what the Titans had hoped, ranking 24th with an 85.4 passer rating. Tennessee’s vaunted ground attack hasn’t exactly been unstoppable, and the Titans have been held to 23 points or fewer in four of their last five games. Don’t be surprised if this game is decided by a late field goal.

Prediction ATS: Cincinnati

Houston Texans (+11.5) at Los Angeles Rams

Tom Savage has started two games for Houston this season. In those contests, the Texans lost by 22 points at home to the Jaguars and by a touchdown at home to the Colts. That doesn’t bode well for their chances on the road against the NFL’s No.1 scoring team. L.A. has scored at least 27 points in all but two games and 33 points or more on five occasions. Savage has one touchdown pass in six quarters.

Prediction ATS: Los Angeles

Dallas Cowboys (+2.5) at Atlanta Falcons

The Cowboys are a legitimate Super Bowl contender. Atlanta is not even playing like a team that will reach the playoffs. Home-field advantage hasn’t meant much for the Falcons, who were beaten by the Bills and Dolphins in their own building. Dallas has won their last three road games by a combined 55 points, and Dak Prescott should put up big numbers with or without Ezekiel Elliott.

Prediction ATS: Dallas

Dak Prescott Dallas Cowboys The Week 10 betting odds favor the Atlanta Falcons over the Dallas Cowboys. Pictured: Dak Prescott looks to pass against the Kansas City Chiefs during the first half at AT&T Stadium on Nov. 5, 2017 in Arlington, Texas. Photo: Ron Jenkins/Getty Images

New York Giants (-1) at San Francisco 49ers

The Giants can’t be this bad, can they? New York is headed for a top draft pick, but they should be in the tier above the 49ers and Browns. If San Francisco finds a way to get their first win of the season, Ben McAdoo probably shouldn’t bother getting on the plane back to New York.

Prediction ATS: New York

New England Patriots (-7.5) at Denver Broncos

Denver is the only place where Tom Brady consistently has trouble. The Broncos have three home wins over the Patriots since 2014, and it's not because of the team’s offense. If Brock Osweiler can avoid committing multiple turnovers, Denver can stay within a touchdown behind what is still an above-average defense. New England is 2-6 against the spread in their last eight games in Denver.

Prediction ATS: Denver

Miami Dolphins (+10) at Carolina Panthers

Carolina should beat Miami, but their offense has been too inconsistent to expect the Panthers to win by double-digits. Since beating the 49ers in the season opener, the Panthers have just one victory by more than six points.

Prediction ATS: Miami