If Week 2 is anything like the opening week of the 2016 NFL season, plenty of underdogs will come out on top. Favorites covered just five of the 16 betting lines in Week 1, losing outright in six of those games.

The Panthers are by far the week’s biggest favorites, according to OddsShark, while the Patriots, Cardinals and Ravens are all nearly favored by a touchdown. Only one betting line has reached seven points, and seven underdogs are getting three points or less.

Below are picks against the spread for every game in Week 2, as well as updated betting odds at Las Vegas and online sportsbooks.

New York Jets (-1) at Buffalo Bills

The Bills could have trouble scoring points all season long, especially against the Jets and their dominant defensive front. Ryan Fitzpatrick usually struggles against defenses led by Rex Ryan, but Matt Forte should do enough in the running game to help New York steal a win in Buffalo.

Prediction ATS: New York

Tennessee Titans (+5.5) at Detroit Lions

Tennessee will have a much easier time moving the ball against Detroit than they did against Minnesota in Week 1. The Titans surrendered two touchdowns off turnovers, something that won’t happen against the Lions, and they should be able to keep things close with an improved running game. In a matchup of two bad teams, grabbing 5.5 points is the smart decision.

Prediction ATS: Tennessee

Kansas City Chiefs (+2.5) at Houston Texans

The Texans have a chance to be good this season, but a win against the Bears isn’t exactly proof that they’ll be a legitimate threat in the AFC. Spencer Ware was more than an adequate replacement for Jamaal Charles in Week 1, and Alex Smith was terrific in the Chiefs’ visit to Houston last year.

Prediction ATS: Kansas City

Miami Dolphins (+6.5) at New England Patriots

After getting beaten by the Dolphins in a pivotal Week 17 game last year, the Patriots aren’t losing to Miami on Sunday. Admitting that he had a poor coaching performance last season, Bill Belichick will have his team more than prepared against an offense that scored just 10 points in the opener. Jimmy Garoppolo was terrific in his first-ever start, and he should find success against a defense that has a banged up front four.

Prediction ATS: New England

Jimmy Garoppolo Patriots Jimmy Garoppolo won his first career start when the New England Patriots visited the Arizona Cardinals on Sunday night. Photo: Getty

Baltimore Ravens (-6.5) at Cleveland Browns

The Browns were the easy pick when the point spread began the week at seven points, but they’re still the right choice as 6.5-point underdogs, even though they’re one of the NFL’s worst teams. Baltimore is better than they were last year, but the Ravens could have trouble scoring points, as evidenced by their one touchdown in Week 1. Josh McCown is probably an upgrade over Robert Griffin III, and he won in Baltimore a year ago.

Prediction ATS: Cleveland

Cincinnati Bengals (+3) at Pittsburgh Steelers

The two teams will be battling for first place in the AFC North all season long, but the Steelers are slightly better than the Bengals. Pittsburgh’s offense looked as good as advertised in the season opener, and they only have five losses against the spread in their last 20 games against Cincinnati, via OddsShark.

Prediction ATS: Pittsburgh

Dallas Cowboys (+3) at Washington Redskins

The Redskins are better than what they showed in Week 1, and they should have a bounce-back performance on Sunday. Kirk Cousins is usually terrific at home, and Dak Prescott won’t be able to make the big plays that Dallas will need from him to steal a victory on the road.

Prediction ATS: Washington

New Orleans Saints (+4.5) at New York Giants

It’s a matchup of the NFL’s two worst defenses from last year. While the Giants’ defense seems to be significantly improved after they added three top free agents to the unit, the Saints don’t appear to be any better. They allowed 35 points at home in Week 1, and New York could score even more points on Sunday.

Prediction ATS: New York

San Francisco 49ers (+13.5) at Carolina Panthers

Don’t be fooled by San Francisco’s 28-0 win in the season opener. They faced maybe the worst quarterback in the league, and Blaine Gabbert is in for a rude awakening against Carolina’s defense. The 49ers were routinely blown out by good teams in 2015, and the case should be the same this year.

Prediction ATS: Carolina

Tampa Bay Buccaneers (+6.5) at Arizona Cardinals

This might be the most difficult game to predict on the entire Week 2 schedule. Jameis Winston looked every bit like a former No.1 draft pick in the season opener, and the Cardinals lost at home to a quarterback making his first career start. But it’s important not to overreact to one game, and Arizona still has one of the NFC’s best teams.

Prediction ATS: Arizona

Indianapolis Colts (+6) at Denver Broncos

The Colts have owned the Broncos in recent years, going 8-1 straight up and 9-0 against the spread. Denver managed to win on opening night, and their defense could get them back to the playoffs, but they’ll have few big wins with Trevor Siemian at quarterback. Even as the Broncos won the Super Bowl last year, nine of their 12 regular-season wins came by just one score, and Sunday should be another close contest.

Prediction ATS: Indianapolis

Atlanta Falcons (+4.5) at Oakland Raiders

There was a lot of hype surrounding the Raiders before the start of the season, and they lived up to expectations in Week 1. Derek Carr and Oakland should have no problem putting up points against a defense that allowed Jameis Winston to throw four touchdown passes.

Prediction ATS: Oakland

Jacksonville Jaguars (+3) at San Diego Chargers

The Chargers are favored because the game is in San Diego, but they have very little home-field advantage. The Jaguars nearly upset the Packers in Week 1, and while they might not be a playoff team, Jacksonville is improved with a potentially explosive offense.

Prediction ATS: Jacksonville

Green Bay Packers (-2.5) at Minnesota Vikings

It’s still unknown if it’ll be Sam Bradford or Shaun Hill at quarterback for the Vikings, but the answer might not matter. The Vikings won in Green Bay last year when Teddy Bridgewater passed for just 99 yards, and their defense could prove to be the best in the NFL by year’s end. Adrian Peterson should bounce back from a subpar Week 1 performance, and Minnesota has a good chance to both cover the spread and win outright.

Prediction ATS: Minnesota

Philadelphia Eagles (+3) at Chicago Bears

Carson Wentz played well at home against maybe the league’s worst team, but it could be a different story when he makes the first road start of his career. Chicago couldn’t hold onto a lead in Houston, but they should be able to hold off one of the NFC’s worst teams if they get out in front.

Prediction ATS: Chicago

Seattle Seahawks (-6.5) at Los Angeles Rams

Seattle still has one of the league's best defenses, and it's hard to imagine L.A. having much success on offense after being shut out in San Francisco. With Russell Wilson likely playing and the Rams getting less than a touchdown, the Seahawks have to be the pick.

Prediction ATS: Seattle

Season Record: 8-8