NFL Week 6 Picks Against The Spread 2018: Predictions ATS, Updated Odds For Every Game

Home underdogs have been extremely successful to start the year, and plenty of teams will have a chance to continue that trend in Week 6. Only eight teams are favored at home on the upcoming schedule. Three teams that sit at .500 or better are home underdogs.

Below are picks against the spread for every game in Week 6 of the 2018 NFL season, as well as updated betting odds at Las Vegas and online sportsbooks. Betting lines and trends are courtesy of OddsShark.

Philadelphia Eagles (-3) at New York Giants

New York’s offense might be turning a corner after scoring more than 30 points for the first time since 2015. Odell Beckham and Saquon Barkley are better playmakers than anyone on Philadelphia, and the offensive line has been much improved over the last few weeks. If Eli Manning decides to actually take some shots down the field, the Giants can upset an Eagles’ team that hasn’t scored more than 23 points in any of their five games.

Prediction ATS: New York

Arizona Cardinals (+10.5) at Minnesota Vikings

The Cardinals have a defense that’s good enough to keep this game within 10 points. Arizona is sixth in opponents’ yards per play over the last three weeks, and the unit is playing much better now that Sam Bradford isn’t constantly giving the ball back to the other team.

Prediction ATS: Arizona

Buffalo Bills (+9.5) at Houston Texans

Houston is close to being a double-digit favorite at some sportsbooks, but others still haven’t set a betting line for Sunday’s game. Could they be worried that Deshaun Watson is hurt after he took a beating last week? With potential questions about Watson’s health and Houston’s inability to score in the red zone, Buffalo is the only play here. The Bills’ defense could keep them in this one with only three NFL teams allowing more yards per play.

Prediction ATS: Buffalo

Tampa Bay Buccaneers (+3.5) at Atlanta Falcons

The Bucs have the NFL’s worst-ranked defense. With all the injuries Atlanta has sustained, their defense might not be much better than that of Tampa Bay. The Falcons have allowed at least 37 points in three straight games. This could end up being the week’s biggest shootout with the victory going to the team that has the ball last.

Prediction ATS: Tampa Bay

Carolina Panthers (+1) at Washington Redskins

Washington stood little chance on the road in Week 5 against New Orleans as Drew Brees broke the all-time passing record. The Redskins' defense will perform much better at home, where they’ve allowed 38 total points to Aaron Rodgers and Andrew Luck. Carolina’s offense has been nothing special, despite three of their four games coming against teams that rank in the bottom half of the league in yards allowed per play. The Panthers have lost four of their last five road games.

Prediction ATS: Washington

Indianapolis Colts (+2.5) at New York Jets

Even though they sit in last place, the Colts are a tough team. They had too many injuries to seriously challenge the Patriots last week. If Indianapolis can force Sam Darnold into situations where he has to make big plays, the Colts have a good chance to come away with the victory.

Prediction ATS: Indianapolis

Pittsburgh Steelers (+2.5) at Cincinnati Bengals

Despite all the controversy that has surrounded the team, Pittsburgh still has an elite offense. Only four teams have scored more points than the Steelers, who did face the NFL’s No.1 defense in their last loss. Cincinnati is one of the teams that is ahead of Pittsburgh in points scored, and they should be able to move the ball fairly well against the Steelers’ poor secondary. But the Bengals’ offense won’t be as effective the rest of the year without tight end Tyler Eifert. The Steelers are 17-6-1 against the spread in their last 24 games against Cincinnati.

Prediction ATS: Pittsburgh

Los Angeles Chargers (-1) at Cleveland Browns

The Browns are remarkably close to being undefeated. Cleveland’s only loss in regulation came by a field goal in New Orleans, and they still haven’t been defeated at home. The Chargers still haven’t beaten a good team this season, and now they’re going on the road to face a defense that’s seventh in opponents’ yards per play. Look for Baker Mayfield and the offense to bounce back after struggling against Baltimore’s stingy defense.

Prediction ATS: Cleveland

Chicago Bears (-3) at Miami Dolphins

The Dolphins clearly aren’t as good as their 3-0 start might’ve indicated, but the Bears shouldn’t be favored by a field goal in Miami. Would Chicago really be favored by nine points at home against the Dolphins? Miami nearly stole a win in Cincinnati last week. Let’s see how Mitchell Trubisky performs on the road after having the game of his life when he last played in Week 4.

Prediction ATS: Miami

Seattle Seahawks (-3) at Oakland Raiders

With this game being played in London, it’s pretty easy to lay the three points. Seattle’s defense has been a little better than expected, despite losing so many stars. The Seahawks are limiting opposing quarterbacks to a 79.3 passer rating. Derek Carr has made some costly mistakes in between completing over 71 percent of his passes, ranking first in the NFL with eight interceptions. That’s not going to cut it when you’ve got a defense that’s allowed more yards per play than 30 other teams.

Prediction ATS: Seattle

Los Angeles Rams (-7) at Denver Broncos

As bad as Denver has looked, it’s hard to bet against them as seven-point underdogs at home, even against the league’s best team. The Broncos might have the NFL’s best home-field advantage, and it showed when they nearly upset the undefeated Chiefs at Mile High. Los Angeles escaped Seattle with a two-point win in Week 5, and the Rams’ Week 6 game could be very similar.

Prediction ATS: Denver

Baltimore Ravens (-3) at Tennessee Titans

Because of how every Tennessee game has gone this season, the Titans are the right play as three-point home underdogs. Since losing by a touchdown in the opener, all four of Tennessee’s contests have been decided by three points or fewer. They’ve allowed 14.8 points per game over the last four weeks, and no team has surrendered fewer yards per play than the Titans over the last three weeks. The Ravens scored just nine points last week, and they are likely in for another low-scoring affair in their third straight road game.

Prediction ATS: Tennessee

Jacksonville Jaguars (-3) at Dallas Cowboys

Here’s another game in which taking the home underdog makes sense in a contest that probably won’t feature many points. Jacksonville and Dallas are both in the top six in opponents’ yards allowed per play. Dak Prescott doesn’t have much to work with this season, but do you really want to bet on Blake Bortles as a road favorite? The quarterback has four touchdown passes and 11 interceptions in his last five regular-season road games, failing to post a passer rating north of 75.6 in any of those matchups.

Prediction ATS: Dallas

Kansas City Chiefs (+3.5) at New England Patriots

The Chiefs won’t stay perfect forever. Not only has Kansas City won all five of their games, but the team has covered the final point spread each week. That could very well change in Foxboro, where the Patriots have outscored their opponents 103-51 in three games this season. New England’s offense is back to being one of the league’s best now that Josh Gordon and Julian Edelman are in the fold. Tom Brady will torch Kansas City’s 31st-ranked pass defense.

Prediction ATS: New England

San Francisco 49ers (+9.5) at Green Bay Packers

Green Bay should take care of business at home the way they did against the Bills two weeks ago as 9.5-point favorites. The Packers haven’t lost at Lambeau Field this season. Aaron Rodgers is looking healthier, and C.J. Beathard still looks like C.J. Beathard. The quarterback has thrown two interceptions in both of his starts, and it’s going to be a long night for the 49ers if the signal caller commits multiple turnovers in Week 6.

Prediction ATS: Green Bay

Season Record: 38-36-4