Only three teams are favored by more than a touchdown in Week 6 of the 2019 NFL season. Road teams have had a historic amount of success through five weeks, but only three teams are underdogs in their own stadium.

Below are picks against the spread for every game in Week 6, as well as updated betting odds at Las Vegas and online sportsbooks. Betting lines and trends are courtesy of OddsShark.

New York Giants (+17) at New England Patriots

The Patriots would blow out a healthy Giants’ team. Now that New York will be without its star running back and two of Daniel Jones’ top three targets, this game could be over by halftime. New England ranks first in just about every major defensive category. It shouldn’t be difficult for Tom Brady and the Patriots to approach 30 points against an awful pass defense.

Prediction ATS: New England

Carolina Panthers (-2) at Tampa Bay Buccaneers (London)

The Panthers have won their last two games in spite of mediocre performances from Kyle Allen. The undrafted quarterback has started to come back to earth, and Tampa Bay has already beaten Carolina once this season when the Panthers got bad quarterback play. Christian McCaffrey might not be able to carry Carolina’s offense against a defense that’s the NFL’s best in terms of opponents’ yards per carry.

Prediction ATS: Tampa Bay 

Houston Texans (+4.5) at Kansas City Chiefs

Be careful betting against a Chiefs’ team that’s coming off a loss. Kansas City’s offense was held in check amid Patrick Mahomes aggravating an ankle injury and the Chiefs dropping a few big passes. There’s a chance Tyreek Hill will return Sunday. Houston’s defense isn’t up to the task of stopping the Chiefs in Arrowhead Stadium.

Prediction ATS: Kansas City

mahomes extension Quarterback Patrick Mahomes #15 of the Kansas City Chiefs watches the video replay against the Indianapolis Colts during the AFC Divisional Playoff at Arrowhead Stadium on January 12, 2019 in Kansas City, Missouri. Photo: David Eulitt/Getty Images

Philadelphia Eagles (+3) at Minnesota Vikings

Keep betting against Kirk Cousins when he faces good teams until the quarterback proves he can beat a true contender. Minnesota’s offense has played well against mediocre competition while struggling against winning teams. Philadelphia remains one of the NFC’s top teams. Carson Wentz will make the plays down the stretch that Cousins can’t.

Prediction ATS: Philadelphia 

Cincinnati Bengals (+11.5) at Baltimore Ravens

Baltimore continues to prove its defense has taken a major step back, allowing Mason Rudolph and Devlin Hodges to post a passer rating near 100.0. Lamar Jackson has four touchdown passes and five interceptions in the last three games. The Bengals are 4-1 against the spread in their last five road games against the Ravens. This game could be closer than some expect.

Prediction ATS: Cincinnati 

Seattle Seahawks (-1.5) at Cleveland Browns

Russell Wilson can’t carry the Seahawks on his back every week. Seattle nearly lost at home in Week 5 when the quarterback was close to perfect. The Seahawks might not be able to pressure Baker Mayfield the way Cleveland’s opponents have done in their three losses. 

Prediction ATS: Cleveland 

New Orleans Saints (+1.5) at Jacksonville Jaguars

The Saints are still one of the NFL’s best teams with Teddy Bridgewater at quarterback. New Orleans shouldn’t be an underdog against a team that likely isn’t going to the playoffs. Jacksonville’s defense isn’t what it once was, ranking 26th in opponents’ yards per play. The Jaguars will struggle to slow down Alvin Kamara a week after Christian McCaffrey had his way with them.

Prediction ATS: New Orleans

Washington Redskins (-3.5) at Miami Dolphins

In a game between two winless teams, take the home team getting more than a field goal. Miami will probably get a victory at some point in 2019. Sunday might be their best chance to slide into the win column.

Prediction ATS: Miami

Atlanta Falcons (-2.5) at Arizona Cardinals

Picking Atlanta to win as a road team against anyone but Miami makes little sense. The Falcons have been an absolute disaster in 2019, losing three games by at least two touchdowns. Kyler Murray could have his best game of the season against a defense that has given up at least 27 points in all three road games.

Prediction ATS: Arizona

San Francisco 49ers (+3.5) at Los Angeles Rams

The Rams are probably still the best team in the NFC West, despite the 49ers’ perfect start. San Francisco’s defense will finally be tested when they take on a team that hasn’t scored fewer than 23 points in a meaningful home game in two years. Jimmy Garoppolo and the 49ers’ offense might not be up to the task. Los Angeles is 4-1 against the spread this season.

Prediction ATS: Los Angeles

Jared Goff Todd Gurley Rams Jared Goff #16 of the Los Angeles Rams hands off to Todd Gurley #30 in the first quarter against the Dallas Cowboys in the NFC Divisional Playoff game at Los Angeles Memorial Coliseum on January 12, 2019 in Los Angeles, California. Photo: Harry How/Getty Images

Tennessee Titans (+2) at Denver Broncos

Denver’s once-great home-field advantage has been nonexistent this season. Tennessee always seems to come up big when they aren’t expected to, going 2-0 straight up as an underdog in 2019. Joe Flacco will struggle against a defense that has surrendered 20 points or fewer in eight of its last nine games. The Broncos are 2-7 against the spread in their last nine games.

Prediction ATS: Tennessee

Dallas Cowboys (-8.5) at New York Jets

Dak Prescott and Co. will get back on track after losing to two very good teams. The Cowboys’ offense was dominant in the first three weeks, scoring more than 30 points each game against a weak schedule. The Jets can’t protect the quarterback. Sam Darnold will only improve the offense so much, coming back from a four-week absence.

Prediction ATS: Dallas

Pittsburgh Steelers (+7) at Los Angeles Chargers

Los Angeles has proven to be the same old Chargers in 2019, continuing to fall below expectations. L.A. is 1-4 against the spread, losing straight up three times as a favorite. Pittsburgh covered the spread in Mason Rudolph’s first start. The Steelers probably should’ve beaten the Ravens in Week 5 with their third-string quarterback seeing significant playing time. 

Prediction ATS: Pittsburgh

Detroit Lions (+4) at Green Bay Packers

Even in the midst of a 4-1 start, Green Bay’s offense still has room to improve. The Packers took advantage of three Dak Prescott interceptions in Week 5 as Dallas outgained them by more than 200 yards. The Lions have been impressive against tough competition, beating the Chargers and Eagles and barely losing by four points to the Chiefs. Detroit is 4-1 against the spread and straight up in their last five meetings with Green Bay.

Prediction ATS: Detroit