Quarterback Baker Mayfield (No. 6) will face Ohio State's tough defensive line. Getty

In a possible early preview of a College Football Playoff matchup, the No. 2 Ohio State Buckeyes host the No.7 Oklahoma Sooners on Saturday in Columbus.

The two teams are coming off contrasting season openers. Ohio State didn't look particularly sharp in Week 1, needing a late charge to hold off Indiana in Bloomington, 49-21. Oklahoma is coming off a blowout win over UTEP, 56-7.

Oklahoma will be looking to ride their hot streak after a big home disappointment last season. The Sooners and Buckeyes met one year ago, with Ohio State quarterback J.T. Barrett leading the offense to a big day in a 45-24 win in Norman, Oklahoma. Barrett antagonized the Sooners' defense, passing for 152 yards and four touchdowns, while rushing for 74 yards.

Things could be much different this time around under first-year head coach Lincoln Riley. The 34-year-old said the coaching staff is prepared for the tough road test after cruising to a victory in his debut.

"In the majority of our career, we’re preparing for games on one week’s notice, and so as far as being the head coach, I don’t know that there’s differences in that for me," said Riley.

The key matchup will be when Oklahoma has possession. Led by quarterback Baker Mayfield, the Sooners boast a strong passing attack. Urban Meyer called Mayfield "a dangerous player," and the Heisman Trophy candidate was basically flawless against UTEP.

Ohio State, meanwhile, has one of the best defensive lines in the nation, though pass defense is considered a question mark for defensive coordinator Greg Schiano.

Oklahoma, who has won 11 straight after last season's loss to Ohio State, will be playing in front of a packed crowd at Ohio Stadium in the Buckeyes' home opener.

"There’s nothing like the home opener, coming out, running down the tunnel, fireworks and stuff," said Ohio State defensive end Tyquan Lewis. "It’s epic."

Prediction: Don't be surprised if this game is a shootout from start to finish. Ohio State should come away with a victory, but it will probably a lot closer than many expect.

Betting Line: Ohio State by 7 points

Over/Under: 63.5 points

Start Time: 7:30 p.m. ET

TV Channel: ABC

Live Stream: Watch ESPN