A group of pharmaceutical companies and distributors agreed to pay $590 million to settle lawsuits connected to opioid addiction among Native American tribe members, according to a US court filing released Tuesday.

The agreement is the latest amid a deluge of litigation spawned by the US opioid crisis, which has claimed more than 500,000 lives over the last 20 years and ensnared some of the largest firms in the world of American medicine.

Pharmaceutical companies McKesson, AmerisourceBergen and Cardinal Health had already struck a separate deal with the Cherokee tribe last September for $75 million.

According to documents filed in an Ohio federal court Tuesday by a committee of plaintiffs, the companies agreed to pay another $440 million over seven years to other Native American tribes.

The pharmaceutical group Johnson & Johnson, for its part, agreed to pay $150 million over two years to all the tribes, of which $18 million are destined for the Cherokee.

Native Americans have "suffered some of the worst consequences of the opioid epidemic of any population in the United States," including the highest per-capita rate of opioid overdoses compared to other racial groups, according to the filing from the Plaintiffs' Tribal Leadership Committee.

"The burden of paying these increased costs has diverted scarce funds from other needs and has imposed severe financial burdens on the tribal plaintiffs."

Johnson & Johnson, McKesson and the other two companies in the accord -- AmerisourceBergen and Cardinal Health -- previously agreed to a $26 billion global settlement on opioid cases.

J&J said Tuesday the $150 million it agreed to pay in the Native American case has been deducted from what it owes in the global settlement.

"This settlement is not an admission of any liability or wrongdoing and the company will continue to defend against any litigation that the final agreement does not resolve," the company said.

It was unclear if the other companies would take their portion under the latest agreement from the global settlement.

Pharmaceutical companies and distributors have agreed to pay $590 million to settle litigation related to opioid addiction in the Native American population
Pharmaceutical companies and distributors have agreed to pay $590 million to settle litigation related to opioid addiction in the Native American population AFP / Eric BARADAT

Robins Kaplan, a law firm negotiating on the behalf of the plaintiffs, said the agreement still must be approved by the Native American tribes.

"This initial settlement for tribes in the national opioid litigation is a crucial first step in delivering some measure of justice to the tribes and reservation communities across the United States that have been ground zero for the opioid epidemic," Tara Sutton, an attorney at the firm, said in a statement.

Douglas Yankton, chairman of the North Dakota-based Spirit Lake Nation, said the money from the settlement would "help fund crucial, on-reservation, culturally appropriate opioid treatment services."

Steven Skikos, an attorney representing the tribes, told AFP the group is pursuing claims against other drugmakers.

"This is hopefully the first two of many other settlements," he said.

Every tribe recognized by the US government, 574 in all, will be able to participate in the agreement, even if they have not filed lawsuits.

Many of the lawsuits regarding the opioid crisis have centered on Purdue Pharma, the manufacturer of OxyContin, a highly addictive prescription painkiller blamed for causing a spike in addiction.

A judge in December overturned the company's bankruptcy plan because it provided some immunity for the owners of the company in exchange for a $4.5 billion payout to victims of the opioid crisis.

The litigation wave has also swamped pharmacies owned by Walmart, Walgreens and CVS, which a jury found in November bear responsibility for the opioid crisis in two counties in Ohio.