Pentagon chief Lloyd Austin and top US diplomat Antony Blinken met their South Korean counterparts in Seoul on Wednesday to bolster a united front against an increasingly assertive China and the nuclear-armed North.

The South is the second leg of the US officials' inaugural overseas trip, and like their first stop, Japan, a leading security ally of the United States.

The Biden administration is focused on rallying alliances with its key Asian partners to counter a rising China.

Before leaving Tokyo, Secretary of State Blinken accused Beijing of acting more repressively at home and "more aggressively abroad", citing its activities in the East and South China Seas and towards Taiwan.

"It's important for us to make clear together that China cannot expect to act with impunity," Blinken said.

Beijing accused the United States and Japan of ganging up to interfere in its internal affairs and attempting to "harm China's interests".

"This is just another clear example of the US and Japan working in collusion to interfere in China's internal affairs," foreign ministry spokesman Zhao Lijian told reporters on Wednesday.

Austin also told South Korean defence minister Suh Wook that their alliance faced "unprecedented challenges posed by both the Democratic People's Republic of Korea and China".

North Korea is moving up the agenda in the South, where the US stations 28,500 troops to defend it against its neighbour.

The allies kicked off joint military exercises last week and North Korean leader Kim Jong Un's influential sister warned Washington this week against "causing a stink at its first step" if it wants to "sleep in peace for coming four years".

Talks between US Secretary of Defense Lloyd Austin (L) and South Korean officials are expected to focus on the North and China
Talks between US Secretary of Defense Lloyd Austin (L) and South Korean officials are expected to focus on the North and China POOL / Chung Sung-Jun

The statement by Kim Yo Jong, a key adviser to her brother, was the reclusive state's first explicit reference to the new leadership in Washington, more than four months after Joe Biden was elected to replace Donald Trump -- although it still did not mention the 78-year-old Democrat by name.

The US envoys will meet on Thursday with President Moon Jae-in, who brokered the talks process between Kim and Trump in 2018.

Trump's unorthodox approach to foreign policy saw him trade insults and threats of war with Kim Jong Un before an extraordinary diplomatic bromance that saw a series of headline-grabbing meetings.

But ultimately no progress was made towards Washington's declared aim of denuclearising North Korea, with a second summit in Hanoi in early 2019 breaking up without an agreement and Pyongyang still under multiple international sanctions for its banned weapons programmes.

Blinken and Austin will consult on a review of Washington's policy towards the North being carried out by the new administration.

But subtle differences between Washington and Seoul could be seen in their readouts of the defence chiefs' meeting Wednesday.

Pentagon press secretary John Kirby said Austin and Suh had expressed commitment to achieving "the denuclearisation of North Korea".

On the other hand Seoul's defence ministry said that they had "shared objectives of achieving the complete denuclearisation of the Korean peninsula and a permanent peace in the region".

The specific "North Korea" phrasing used by Washington is anathema to Pyongyang, which prefers the broader and more ambiguous reference to the peninsula as a whole, terminology that could be taken to include the US nuclear umbrella over the South.

The difference threatens to put Seoul on the horns of a diplomatic dilemma: since Hanoi, Moon's administration has repeatedly tried to reach out to Pyongyang but has been regularly rebuffed.