One day after she was acquitted of the murder of her British roommate Meredith Kercher, Amanda Knox was headed home to Seattle, Washington to try and live a normal life.

Knox left her prison outside of Perugia, Italy Monday night just two hours after her verdict was read.

By Tuesday morning, Knox was spotted by several media outlets at Fiumicino airport in Rome. Knox walked in the middle of a large group of guards.

The Italy-USA Foundation confirmed that the American was in Rome boarding a flight to London where she will catch a connecting flight to the States.

Conrrado Maria Daclon, secretary general of the Italy-USA Foundation, accompanied Knox on her journey from Perugia to Rome.

During the trip from Perugia to Rome, Amanda was serene, even with all the strong and contrasting emotions that she felt as she glimpsed freedom for the first time after four long years in which she was wrongly locked up in a cell, Daclon told The Telegraph.

Amanda told me that she was really keen to publically thank the many Italians who supported her in these years of unjust incarceration and who believed in her and in her innocence.

She confirmed to me that in the future she'd like to return to Italy, Dalcon added.

Knox also issued an open letter to Italians through an Italian-American foundation thanking those who wrote, those who defended me, those who were close, those who prayed for me. I will be forever grateful to you. I love you, Amanda.

Raffaele Sollecito

Meanwhile, Knox's former boyfriend Raffaele Sollecito, who was also acquitted of the murder on Monday, returned home to the southern Italian city of Bari on Monday.

He is trying to recover himself. He is going around touching things as if he is a child who needs to take back the things of his life, to acquire forgotten elements, Sollecito's father said in a statement to the press.

An Appeal?

Prosecutor Giuliano Mignini has said he will appeal the ruling.

The (higher) court will decide whether to confirm the first sentence or the second sentence, he said in a statement.

Let's wait and we will see who was right. The first court or the appeal court. This trail was done under unacceptable media pressure. The decision was almost already announced; this is not normal, he added.

If the highest court overturns the acquittal, prosecutors would be free to request Knox's extradition to Italy to finish whatever remained of a sentence. It is up to the government to decide whether they make such a request.

Many in Italy would likely agree with Mignini. Hundreds of mostly university-aged people gathered in the piazza outside the courtroom in Perugia on Monday, jeering in protest.

The Kercher Family

It was obviously a very long and difficult day yesterday, Meredith Kercher's brother Lyle told the press on Tuesday. Ultimately while we accept the decision and respect the court and the Italian justice system we do find now that we are left looking at this again and thinking how a decision that was so certain two years ago has been so emphatically overturned now.

For us it feels like back to square one and the search goes on for what really happened, he added

The Kerchers had urged the court to uphold the guilty verdicts passed two years ago, and resisted theories that a third man convicted in the case, Rudy Guede, had acted alone.

They have also complained that the legacy of Meredith has been left out of the case and the constant media coverage.

What's Next?

Less than 24 hours after the verdict was read, news organizations were offering as much as one million dollars for the first interview with Knox.

British tabloids were back in action too, poking fun at Knox's celebrity. One Daily Mail headline read Weeping Foxy is Freed to Make a Fortune.

Donald Trump, who has long championed Miss Knox's innocence and previously called for a US boycott of Italy until Knox was freed, said that Knox could become a big star.

For her to have spent four years in a terrible jail is just outrageous. I don't think they (the Knox family) can leave quick enough. She went to Italy to learn the language. Well, she learned the language, Trump said in a statement.

Amanda Knox left the United States an unknown 20-year-old student and returns as one of the most recognizable names in the country. Intimate details of her life were dug out by the tabloid press painting the young women as a ruthless sex-crazed she-devil.

Then, the television-watching public became acquainted with Knox's tireless parents who spent the past four years campaigning for her life, tearing apart the foxy knoxy reputation and replacing it with something more wholesome, more relatable. Knox came to be seen as a naïve young woman caught up in a judicial nightmare.

While Knox is well aware of the media hype around the case, she's spent the past four years in prison and - unlike her media-savvy parents - may not have a full comprehension of the circus surrounding her plight.

Though she has expressed an interest to return to the life she left behind, there are questions of whether or not that is even possible. The Telegraph reports that Knox will undergo a period of readjustment during which time her whereabouts will not be public.

Will she become a reality star or will she fade into obscurity? The fate of Amanda Knox remains to be seen.