FX’s “American Horror Story: My Roanoke Nightmare” is off to a seriously spooky start and it’s going to get a whole lot weirder in the coming weeks.

Creator Ryan Murphy recently sat down for an interview with Entertainment Weekly where he opened up about what’s to come in Season 6. During the chat he discussed connections to past seasons, comparing Lady Gaga’s character to the First Supreme from “Coven.” Murphy suggested that he intends to further explore Season 3’s witchy theme in a future installment of “American Horror Story,” but not Season 6.

He also confirmed that “American Horror Story” fans should expect a major twist to kick off in episode 6, which airs Wednesday. This was briefly revealed in a preview for the episode following the Oct. 12 show and starred Cheyenne Jackson seemingly giving a ghost tour. The promo revealed nothing more to fans and Murphy has remained tight-lipped while talking about the show.

Here’s everything we know so far about Season 6, episode 6 of “American Horror Story” so far:

This Twist Is Going To Be Huge:

Speaking with EW, Murphy said that the “My Roanoke Nightmare” plot twist is “the biggest” in “American Horror Story” history.

The Show Is Going To Be Turned On It’s Head:

In addition to sharing with fans that the twist is going to be major, Murphy opened up about how he and the writers came up with it. He told EW that Season 6 was essentially created as two separate shows. This suggests that when the twist occurs in Wednesday’s episode, everything viewers have learned so far about the cast and characters will change.

“The season was sort of written as if the season was two different shows,” he said. “Something happens where half the cast is revealed to be playing and doing something absolutely different than you’ve seen in the first five. There’s a startling announcement at the end of act 3 that resents the rest of the season up until episode 10.”

Nothing Is As It Seems:

In a September sit-down with EW, co-creator Brad Falchuk said that episode 6 is the first episode that shows fans that while they think they’ve finally figured out the theme and plot of “American Horror Story” Season 6, they really have no idea.

“Even though the subject matter has gotten out, it’s irrelevant because nobody gets what we’re doing,” Falchuk said. “No matter what you think it is, it’s not that. Then, episode 6 comes and you’re like, ‘Wait! What happened?’”

Evan Peters Will Play A Major Part:

Fans went wild on Twitter for five long episodes, questioning where Evan Peters — who has been a staple in the “American Horror Story” cast since its earliest days — was and when he would be getting some screen time. Finally in episode 5, viewers were introduced to Edward Philippe Mott (Evan Peters), the art-loving, socially awkward original owner of Matt (Cuba Gooding Jr.) and Shelby’s (Sarah Paulson) haunted farm house.

As quickly as he was introduced, he was killed off by The Butcher (Kathy Bates), returning only to save Matt and Shelby from being killed. He helps them escape the property, but it seems we haven’t seen the last of the actor just yet. During an interview with E! Online, Murphy promised much more of Peters, adding that this is “one of the greatest” things the young actor has done to date.

“Evan Peters in episode 6 is one of the greatest, most hilarious things Evan has ever done and he loved it. He’s a very big, pivotal part of episode 6, playing a completely different character than what we’ve seen him play,” Murphy teased. “Evan is just the best, I love him.”

The Cast Will Assume New Roles:

In addition to shaking up the plot, it seems a majority — if not all — the characters we’ve met so far will be assuming new roles during or after Season 6, episode 6 of “American Horror Story.” Neither Murphy nor his co-creator would provide any insight as to who will be playing what once the change happens, but he did share that some “American Horror Story” favorites will debut in and after episode 6.

Taissa Farmiga, who starred in both the original series and “Coven,” and Finn Wittrock, who appeared in “Freak Show” and “Hotel,” will join the “My Roanoke Nightmare” cast. It is unclear who their characters are, but Murphy assures fans that Wittrock is taking on his most off-the-wall role yet.

“Finn Wittrock is coming back soon, playing his most f---ed up character of all time,” Murphy told E! News. “To the point where he was like, ‘This is so crazy that I don’t know if I can do it, but I’ll do it.’ And Taissa Farmiga is coming back for the first time ever since ‘Coven,’ in I think a really, really great part and we love her.”

Confused? You should be. Tune in to “American Horror Story” Season 6, episode 6 Wednesday at 10 p.m. EDT on FX.

“American Horror Story” Major changes are coming to “American Horror Story” Season 6 in episode 6 — here’s what to expect. Photo: FX