Real Madrid sewed up the La Liga title last week and Barcelona is well clear of the rest of the table in second place, while Espanyol is bound to finish mid table regardless of the outcome.
Lionel Messi will undoubtedly look to add to his eye popping 68 goal tally, pushing the single season record ever higher, and the Barcelona should have incentive to win in Pep Guardiola's final home La Liga game.
Espanyol will be looking for a chance to knock off a giant and one of their main rivals. It is a tall task, especially at Camp Nou, but they will give great effort.
Where to watch: The game can been seen online here for free starting at 3 p.m. ET.
G: Pinto D: Adriano, Mascherano, Bartra, Montoya M: Keita, Thiago, Fabregas F: Pedro, Afellay, Messi
G: Alvarez D: Didac, Forlin, Rodriguez, Lopez DM: Baena, Romaric AM: Coutinho, Verdu, Weiss F: Uche
Prediction: Espanyol's determination and the rotation from Barcelona will make this a closer game than it might have been but the quality of Barcelona will show through.
Predicted Score: Barcelona over Espanyol 3-0