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Hillary Clinton's Twitter account was paying close attention to the GOP debate Wednesday night. Reuters

Republican candidates, Hillary Clinton is watching you, and she does not approve. Clinton, the Democratic front-runner, kept a close eye on the GOP candidates during Wednesday night's Republican debate hosted by CNN, or at least her campaign's Twitter account did. Clinton reacted to the jabs and policy comments made by the GOP candidates throughout the debate.

She wasn't the only Democrat looking to grab the spotlight from Republican front-runner Donald Trump. Democratic presidential hopeful Bernie Sanders also got into the action. His Twitter account posted: "Will they ever talk about climate change as a foreign policy issue? Or talk about it all?"

The event hosted by CNN at the Ronald Reagan Presidential Library featured the top 11 Republican presidential candidates according to an average of public polls. It marked the second GOP primary debate of the 2016 campaign with the Iowa caucuses less than five months away.

"These debates are increasingly life-and-death moments for candidates who started out as the presumptive frontrunners but have fallen to low single digits," Republican strategist Steve Schmidt, a former aide to George H. W. Bush who advised John McCain in 2008, told CNN before the debate. "The first step to securing the nomination, is taking control of your destiny, completely within the process."

Going into Wednesday night’s debate, Trump was in first place with 27 percent, with retired neurosurgeon Ben Carson in second with 23 percent, according to a recent poll. The other Republican candidates invited to the prime-time forum were former Florida Gov. Jeb Bush, Wisconsin Gov. Scott Walker, U.S. Sen. Ted Cruz of Texas, U.S. Sen. Marco Rubio of Florida, former Arkansas Gov. Mike Huckabee, U.S. Sen. Rand Paul of Kentucky, Ohio Gov. John Kasich, former Hewlett-Packard CEO Carly Fiorina and New Jersey Gov. Chris Christie.