When and Where: The La Liga match kicks off in Seville at 4 p.m. ET. The game is being streamed online, via ESPN3.
Preview: Real Madrid go into Saturday's contest on an incredible run of 10 consecutive victories in La Liga. Sitting a massive 10 points clear of bitter rivals Barcelona in the league standings, Real know that they simply have to avoid a meltdown in the final 13 games of the season in order to become champions
With the second-leg of their Champions League round-of-16 tie coming up in midweek against CSKA Moscow, Real will need to avoid taking their eyes of the ball in Seville.
But that possibility will be little consolation to Betis, who are facing a side that have won 10 of their 12 away games in La Liga this campaign, conceding just six goals in the process.
While Betis will surely view anything they can glean from this encounter as a bonus, the points will come in handy with Pepe Mel's side only six points above the relegation zone.
Team News: Karim Benzema is nearing a return to fitness for Los Blancos, but it is not expected to make it in time for Saturday's game. Angel Di Maria and Fabio Coentrao are also going to miss the match through injury, while Ricardo Carvalho is serving a suspension. Fellow Portuguese defender Pepe will return from his ban, though, and is expected to replace Carvalho in the center of defense.
For Betis, forward Jonathan Pereira will be out after receiving his fifth caution of the season in the team's last outing. Betis' main problems, though, are in defense where Antonio Amaya will be missing and Paulao is a big doubt with a bruised leg. Paulao has been included in the match-day squad, however, and Mel will be hoping he can recover in time to play a full part.
Prediction: Jose Mourinho will make sure that his Real Madrid players focus on getting the La Liga title sewn up as soon as possible. Especially with Betis' problems at the back, it is hard to see them giving Real too much resistance in their quest to end Barcelona's reign as La Liga kings.
Betis 0-3 Real Madrid