Congressional leaders withheld any support for Rep. Anthony Weiner, D-NY after he admitted sending lewd photos to a Seattle woman and saying he had 'inappropriate' online relationships with six women in total.

House Republican Leader Eric Cantor, R-VA, has called on colleague Rep. Anthony Weiner, D-NY to resign a day after the embattled New Yorker admitted to sending explicit photos of himself to women he met online.

I think he should resign, Cantor told reporters while on a trip in Virginia, according to Reuters.

We've got a lot of serious challenges going on in this country and a lot of work for Congress to do. The last thing we need is to be immersed in discussion about Congressman Weiner and his Twitter activities, he said.

Weiner, when told of Cantor's words, was defiant.

He's entitled to his viewpoint. I'm not resigning, no, he told CNN.

Senate Democratic Leader Harry Reid said he wouldn't even give Weiner advice, but stopped short of calling for his resignation.

He was asked what he would say if Weiner asked for his advice.

Call somebody else, Reid told reporters at a press conference in the Capitol as part of a wider press conference.

I wish there was some way I could defend him, but I can't, he said.

On Tuesday, House Democratic Leader Nancy Pelosi made public a letter issued to the House ethics committee calling for an ethics probe, noting Weiner disclosed conduct which he described as inappropriate.

An investigation to determine if he broke the House rules is warranted.

A day earlier she said she was deeply saddened about the situation for Weiner's wife, family, staff and constituents.

She called for a probe to determine whether any official resources were use.