"Fashion Police" star Giuliana Rancic is finally speaking out about speculation regarding her health. Rumors regarding the E! News host's weight have long circulated suggesting that the 40-year-old is either once again battling cancer or suffering from an eating disorder.

Since being diagnosed with breast cancer in 2011, Rancic has lost a considerable amount of weight, causing widespread concern among E! viewers. Sites like Radar Online attributed her severe slim-down to job stress. While she has fired back at critics of her weight before, she typically remains tight-lipped on the matter. Now, Rancic claims the speculation has simply "gotten out of hand" and said is ready to put the rumors to bed once and for all. 

"Some people were saying, 'The cancer is probably back,'" Rancic told People magazine Wednesday. "And they were accusing me of every eating disorder. I thought to myself, 'God, if someone really thought I had an eating disorder, that a horrible way to approach it.'"

The longtime E! News anchor says she's healthy on all accounts. Rancic told the magazine she has been cancer-free since her double mastectomy in 2011 and assured readers she is "eating a lot."

"I eat more than any of my friends," she said. "I eat a very robust, healthy, balanced diet and dessert almost every night. I"m not hiding from anything."

The mother-of-one attributes her frighteningly thin appearance to cancer-suppressing medications she's prescribed. According to People, she was warned the medication could alter her metabolism, causing weight loss, though she was not aware just how much weight she would lose. 

Although she makes a living critiquing celebrities for their appearance on "Fashion Police," Rancic says the criticism has weighed heavy on her. What's more, she claims there is little she can do about it.

"It's really hurtful," she said. "I'm sorry that some people think I'm disgustingly skinny, as they put it, but there's nothing I can do. I'm lucky that I even have the type of cancer that reacts to the medicine."

Rancic told People she's aware that she's "really thin" and admits she struggles to accept herself as "beautiful and sexy" without the opinions of a thousand strangers being thrust at her daily. She claims her weight has affected her personally and professionally, as she says she was recently rejected for a project with a major publication as they claimed she was "too skinny."

"I never want my weight to distract people from what I do," she said. "But it is becoming a distraction, [whenever] I wear something sleeveless, show my arms, my back."