Cain called Pelosi the derogatory nickname during the CNBC GOP debate on Wednesday after referring to a bill while she was serving as the Speaker of the House in Congress.
He said a healthcare reform proposal died because Princess Nancy sent it to committee where it never made it further, though he would have wanted it that way.
Following his name-calling, the audience applauded, seemingly amused by his comment.
Herman Cain also took the time to address the alleged sexual harassment charges brought upon him recently.
The American people deserve better than someone getting tried in the court of public opinion based on unfounded accusations, Cain said about the allegations of inappropriate conduct with women.
Do you think Cain's Princess Nancy comment was funny or inappropriate towards women? Sound off in the comments below.