When and Where: The semi-finals of the ATP Masters 1000 event in Monte Carlo get underway at 7 a.m. ET on Saturday. A live stream of both matches will be available via ESPN3. Live streaming coverage is also available with a subscription to Tennis TV, through the tournament website.

Preview: The question on everyone's mind as the semi-finals get underway at the first clay-court ATP Masters 1000 event of the year is can anyone beat Rafael Nadal? The Spanish legend on the dirt has won an incredible 40 straight matches at the Monte Carlo Country Club as he has helped himself to seven-straight titles.

But the current French Open champion may face his toughest task to date to keep that run going this year, with an in-form World No. 1 Novak Djokovic a potential final opponent.

But first both men will have to overcome potentially tough semi-final opponents in order to set-up the final that most neutrals are salivating over.

In the first match, Djokovic goes up against Czech danger-man Tomas Berdych. The sixth seed took out world No. 4 Andy Murray on Friday in an impressive three-set win. And the 26-year-old with a rasping forehand will be competing in his second Monte Carlo semi-final having lost out to Nadal back in 2007.

Djokovic, who progressed to the last four with a win over Robin Haase, is playing for a lot more than purely the desire to claim his first Monte Carlo title.

The world No. 1 discovered right before his match in the fourth round with Alexander Dolgopolov that his grandfather had died. Incredibly, he has managed to overcome the emotional turmoil to continue through the draw.

Today was a bit better, but still a lot of emotional ups and downs throughout the match, Djokovic said after his quarter-final win, according to the official tournament website.

But look, I'm playing tennis. I'm very satisfied that I was able to compose myself and get on the court and try to win matches. I got to the semi-finals, which is big result for me under the circumstances.

I was very close to him, so it was a big loss for me and all the family. But he's with me, I know that, in spirit.

Despite the off-court trauma, Djokovic will be favorite to progress to the final, not least because of the 8-1 winning record he holds in head-to-heads with Berdych.

In the day's second semi-final, Nadal takes on Frenchman Gilles Simon. The ninth seed overcame countryman Jo-Wilfried Tsonga in an impressive straight-set win on Friday, as he recorded successive victories over top 10 players in a tournament for the first time in his career, having taken out Janko Tipsarevic in the previous round.

Saturday's contest will also mark the first time the 27-year-old has appeared in a Masters clay-court semi-final.  But the world No. 15 will have to produce something special to get close to the imperious Nadal.

The world No. 2 has so far overcome any fears about a knee injury that forced him to withdraw in Miami, as he has made the last four without the loss of a set.

With Nadal leading the series between the pair 4-1, with all four victories coming in straight sets, it would be a major shock if Simon is able to seriously threaten Nadal's unbeaten streak.