The game kicks-off at 8pm eastern time, and you can watch streaming online here.
Houston defeated the San Francisco 49ers 20-9 last week, thanks to a smothering defense that only allowed three third down conversions.
Texans' quarterback Matt Schaub went 11-for-14 for 128 yards and one touchdown, and former Tennessee running back Arian Foster carried 10 times for 46 yards.
LSU product Trindon Holliday also returned a punt 87 yards for a touchdown in the fourth quarter. It was Holliday's second return for a touchdown this preseason, as he returned another for 90 yards against the Carolina Panthers.
The Texans defense has only given up 22 points in the preseason, and has a chance to shut down the high-powered New Orleans offense.
In their 27-24 loss to the Jacksonville Jaguars last week, the Saints gave up 170 yards rushing at 5.5 yards per carry despite the absence of Jacksonville's top rusher Maurice Jones-Drew.
Former Super Bowl MVP Drew Brees went 10-for-13 for 122 yards and a touchdown, and his back up Chase Daniel contributed two more touchdowns while going 16-for-21 for 185 yards.
The quarterbacks played well, but the defense lost three of its top linebackers against the Jaguars. Strong side linebacker Chris Chamberlain tore his anterior cruciate ligament and was placed on injured reserve. Linebackers David Hawthorne (knee) and Curtis Lofton (ankle) will not play tonight and could miss the season opener.
Prediction: New Orleans will have to slow down the Texans rush attack to give Brees more opportunities to score. However Houston's defense looks as dominant as last season. The Saints will need to speed up their offensive series to tire out the Texans defense.
Predicted Score: New Orleans 31, Houston 17