The Cardinals and Seahawks pulled off two of the biggest upsets of the young season. Arizona went to New England and beat the Super Bowl favorite Patriots. Seattle blew out Dallas 27-17. The Cowboys were coming off a victory against the defending champion Giants.
The San Francisco 49ers now have the best Super Bowl odds, after beating the Lions on Sunday night.
New Orleans is the only playoff team from last year that has started the 2012 season at 0-2. Despite their two losses, the Saints performance is not reflected in the Week 3 betting lines. They are the biggest favorites, giving nine points to the Kansas City Chiefs.
The Giants are expected to win the second Thursday night football game of the year. New York is a 1.5-point favorite over underdog Carolina.
Most of the games are supposed to be close, as there are no double-digit point spreads.
For the first time this season, one game is a pick'em on the schedule. Houston visits Denver, and the contest is expected to be a toss-up. Peyton Manning is coming off a three interception performance in the Broncos "Monday Night Football" loss to the Falcons.
Below are the complete betting lines for all the Week 3 games, including the point spreads and totals. These are the consensus odds from multiple sportsbooks in Las Vegas.
New York Giants (-1.5) at Carolina, 51.5
St. Louis (+7.5) at Chicago, 44.5
Tampa Bay (+7) at Dallas, 46.5
San Francisco (-7) at Minnesota, 43.5
Detroit (-3) at Tennessee, 47
Cincinnati (+3.5) at Washington, 48.5
New York Jets (-3) at Miami, 40
Kansas City (+9) at New Orleans, 54
Buffalo (-3) at Cleveland, 43.5
Jacksonville (-2.5) at Indianapolis, 42.5
Philadelphia (-4) at Arizona, 43.5
Atlanta (+3) at San Diego, 47.5
Houston (PK) at Denver, 46.5
Pittsburgh (-4.5) at Oakland, 44
New England (-3) at Baltimore, 49
Green Bay (-6) at Seattle, 46.5