Tornados are reeking havoc in cities across the mid-west and Memphis may be next in line for a pummeling.

The greatest threat for Wednesday night is between Memphis, Tenn., and Evansville, Ind., and neighboring parts of Arkansas, Illinois, Kentucky and Missouri.

Other parts of the Plains and upper South could see storms, too, before the bad weather moves east Thursday and Friday.

The Storm Prediction Center at Norman, Okla., upgraded the severe weather warning for the middle Mississippi Valley to high risk.

The twister follows one that that just reeked havoc on the small town of Joplin Missouri, killing 117 people -- one of the deadliest on record.

More deaths have resulted from outbreaks of multiple tornadoes.

On April 27, a pack of twisters roared across six Southern states, killing 314 people, more than two-thirds of them in Alabama.

Speaking from London, President Barack Obama said he would travel to Missouri on Sunday to meet with people whose lives have been turned upside down by the twister.

U.S. weather experts say a major tornado outbreak and severe storms are set to hit the MidWest again on Wednesday afternoon and evening as a deadly storm season continues to threaten after weeks of destruction.

Conditions are favorable for long-track, violent tornadoes in both the Moderate Risk and High Risk areas, the National Weather Service said in an update Tuesday.

Tornadoes are expected to hit the mid-Mississippi and lower Ohio Valleys, according to NWS.

The American people are by your side, Obama said. We're going to stay there until every home is repaired, until every neighborhood is rebuilt, until every business is back on its feet.