The companies whose shares are moving noticeably in pre-market trade Wednesday are: Demand Media Inc., Arena Pharmaceuticals Inc., Fossil Inc., Banco Santander, EXCO Resources Inc., Ford Motor Co. and Newmont Mining.

Demand Media Inc. (DMD) stock climbed 22.07 percent to $9.68 in pre-market session. The company raised its outlook for the full year 2012. It reported a first-quarter net loss of $1.8 million compared to a net loss of $5.6 million last year.

Arena Pharmaceuticals Inc. (ARNA) stock rose 2.34 percent to $3.50 in pre-market trading. The FDA has asked for an evaluation of the company’s experimental weight loss pill, lorcaserin, for potential risks of mammary tumors.

Fossil Inc. (FOSL) stock rose 1.88 percent to $80 in pre-market trading. The stock has a 52-week low of $69.57, a 52-week high of $139.20 and $4.93 billion in market capitalization.

Banco Santander (STD) shares plunged 5.49 percent to 6.02 in pre-market trading. Renewed concerns on the European debt crisis following the Greek elections must be worrying investors. The bank, with a market capitalization $57.82 billion, had already seen a lowering of long- and short-term counterparty credit ratings by S&P.

EXCO Resources Inc (XCO) shares slumped 3.49 percent to $7.46 in pre-market trading. The company had a first-quarter net loss of $281.65 million compared with a profit of $21.94 million last year. Also the total revenues for the first quarter fell to $134.85 million from $161.23 million in the earlier year.

Ford Motor Co. (F) stock declined 1.51 percent to $10.45 in pre-market trading. The stock has a 52-week low of $9.05, a 52-week high of $15.35 and $40.49 billion in market capitalization.

Newmont Mining (NEM) stock fell 1.21 percent to $44.22 in pre-market trading. This is the 52 week low of the stock which has a market capitalization of $22.18 billion.