When and Where: The second leg of the Champions League quarter-final kicks-off at 2.45 p.m. ET from the Santiago Bernabeu. A live stream will be available, with a subscription, via FoxSoccer2Go.

Preview: For Cypriot minnows Apoel Nicosia, the opportunity to play in the famous surroundings of the Santiago Bernabeu offers a reward for what has been a fabulous run in this season's Champions League.

And that is surely the extent of their ambitions for Wednesday night.

Trailing 3-0 form the first-leg to giants Real Madrid, to say that Apoel face a momentous task to overturn their deficit in the return match of their Champions League quarter-final would be a massive understatement.

Real Madrid have won all their matches at home in this season's Champions League and have failed to win just five times in 26 matches at the Bernabeu during the campaign in all competitions.

With everything pointing in their favor, Real boss Jose Mourinho is trying to avoid complacency creeping in ahead of the match.

We got a very good result [in Cyprus] but we must respect Apoel. We are going to play against a strong team, Mourinho said, according to Uefa.com.

Real continued their free-scoring season by winning 5-1 at sixth-place Osasuna at the weekend to maintain their six-point advantage over Barcelona atop La Liga.

Apoel warmed-up for their daunting task with a 2-1 over local rivals Omonia to begin their end-of-season playoffs.

Team News: Despite Mourinho has claiming that he will not make big changes to his lineup for Wednesday's game, it would be a surprise if that were not at least one or two alterations. Pepe who has been suffering from a domestic ban will play against Apoel, according to Mourinho. Nuri Sahin, who made a rare start in the first match in Nicosia could again be given a run out.

Real will be without Lassana Diarra, Ricardo Carvalho and Sami Khedira, while Alvaro Arbeloa is being given the night off.

Apoel will be boosted by the return of key left-sided midfielder Gustavo Manduca, after the Brazilian was suspended for the first leg.

Prediction: This match is sure to be nothing but a formality for Real to seal their progress to a mouth-watering semi-final with Bayern Munich. Apoel have been the Cinderella story of this season's Champions League and it would be be sad to see them bow-out with a humiliating defeat.

Fortunately for the Cypriot side, with two important La Liga games to come in the next week, Real can be expected to take their foot off the gas in the second half.

Real Madrid 3-0 Apoel