The NBA even had to change the basketball hoops because of the 7'1, 300-plus pound center's ability to bring it down, which he did on two occasions.
Fans will also remember the epic feud he had with teammate Kobe Bryant, which culminated with O'Neal demanding a trade from the Lakers to the Miami Heat.
But there are also fans who will remember the personality he brought to the game with his youthful charm, his countless charitable acts, and his desire to make people laugh.
Here are some of the best quotes from O'Neal:
I'm a very quotatious person.
Me shooting 40% at the foul line is just God's way to say nobody's perfect.
I've won at every level, except college and pro.
Phil took us to the finals three out of the five years and you want to fire him and want to bring in Mike Krzyzewski? Come on, man. That's like being married to J-Lo, then dropping J-Lo for a girl that's 5-10, 480 (pounds).
I'll take 14 out of 15 any day of the week, any week of the month, any month of the year, any year of the century. I don't know what comes after century. -- On having the Heat's 14-game winning streak snapped.
When asked about his injury that had sidelined him for a considerable amount of time: I'm in Sean-Rooks shape.
I would like to be referred to as 'The Big Aristotle.'
Our offense is like the Pythagorean Theorem. There is no answer.
I'm tired of hearing about money, money, money, money, money. I just want to play the game, drink Pepsi, wear Reebok.
We're focusing on the whole pie, not a slice. A slice is good, but it's not good enough to get you fat. We're trying to get fat.
I am the number one Ninja and I have killed all the Shoguns in front of me.
I'm very excited about my new agreement with the Heat....This contract allows me to address all of my family's long-term financial goals while allowing the Heat the ability to acquire those players that we need to win a championship.
When asked about how his injury will boost the confidence of the Heat: It's sort of like in the movie The Karate Kid when Daniel said he needed Mr. Miyagi. And Mr. Miyagi gave him that confidence to believe he really didn't. These guys think they really need me right now, but they don't. When I come back, we'll all need each other to step up our games and do what needs to be done.
Y'all reporters like my quotes, don't you. Yeah, my quotes are Shaqalicious.