Michigan had a chance to slow the South Carolina final drive, but a few defensive miscues helped the Gamecocks' offense move the ball 70 yards for the decisive score.
Quarterback Connor Shaw stepped up for South Carolina. He threw for 224 yards on 18 completions and 26 attempts. Shaw also rushed for 96 yards on 11 carries.
South Carolina never trailed in the first half, but Michigan stormed back in the third quarter. Wide receiver Jeremy Gallon led the Wolverines with nine completions for 145 yards and two touchdowns.
Quarterback Devin Gardner completed 18 of his 35 passes for 214 touchdowns and three touchdowns. Denard Robinson rushed for 100 yards on 23 carries for Michigan.
The loss drops Michigan to an 8-5 record, while South Carolina improved to 11-2.