Futures on major U.S. indices point to a slightly higher opening on Wednesday, ahead of economic data including ADP national employment report and ISM non-manufacturing index.

Futures on the S&P 500 are up 0.11 percent, futures on the Dow Jones Industrial Average are up 0.12 percent and Nasdaq100 futures are up 0.01 percent.

The ADP report, which is a measure of the monthly change of nonfarm private employment, is due to release at 8:15 am EDT. Economists are estimating private payrolls may rise by 200,000 in April after increasing 201,000 in March.

ISM non-manufacturing index is due to release at 10:00 am EDT, which is expected to show a reading of 57.40 in April compared to 57.30 in March.

Other economic data including MBA Mortgage Applications, Challenger Job Cuts and crude oil inventories are due to release during the day.

US stocks ended lower for the second day on Tuesday, led by declines from commodity producers due to lower oil and gold prices.

The euro advanced 0.29 percent to 1.4829 against the dollar and the yen declined 0.25 percent against the greenback.

Crude oil futures declined 0.07 percent to $110.97/barrel and gold futures fell 0.29 percent.

European stock markets are currently trading mixed with FTSE 100 down by 29.42 points, DAX30 up by 8.88 points and CAC 40 up by 5.17 points.