Uncertainty about the fiscal stability of Greece, Portugal and Spain caused U.S. investors to pull back from early gains, even as Greek and European Union officials said there was no chance of a Greek default or EU bailout.
Sovereign debt issues continue to weigh on the market, said Robert Francello, head of equity trading for Apex Capital in San Francisco.
The pattern has been to sell into the weekend, wait for sovereign risk and sovereign default news in Europe, and if it doesn't happen, the relief rally begins.
Major indexes initially rose more than 1 percent after a host of reports showed the U.S. economy grew at a much stronger-than-expected pace during the fourth quarter and pointed to continued improvement in the first quarter.
But the broader market lost ground by midday as investors sold off shares of such technology bellwethers as Apple Inc , Microsoft Corp and International Business Machines Corp .
The PHLX Semiconductor index <.SOXX> dropped 3.4 percent, weighed down by a soft profit forecast from flash memory maker SanDisk Corp , which tumbled 11.7 percent to $25.42.
The Dow Jones industrial average <.DJI> dropped 53.13 points, or 0.52 percent, to 10,067.33. The Standard & Poor's 500 Index <.SPX> lost 10.66 points, or 0.98 percent, to 1,073.87. The Nasdaq Composite Index <.IXIC> fell 31.65 points, or 1.45 percent, to 2,147.35.
The recent sell-off has seen the S&P 500 tumble 6.7 percent in the last eight trading sessions.
For the week, the Dow lost 1.1 percent, the S&P 500 fell 1.7 percent and the Nasdaq lost 2.6 percent.
For January, the Dow slid 3.5 percent, the S&P 500 shed 3.7 percent and the Nasdaq tumbled 5.4 percent.
Shares of Apple lost 3.6 percent to $192.12 and ranked as the heaviest weight on the Nasdaq, while Microsoft's stock fell 3.4 percent to $28.18. IBM slipped 1.1 percent to $122.39.
Big manufacturers, including Boeing Co , as well as the energy and materials sectors fell, weighing on both the Dow and the S&P 500 after Honeywell set a first-quarter profit target that fell short of analysts' expectations.
Boeing shed 3.1 percent to $60.60 while Honeywell lost 3 percent to $38.64.
Volume was light on the New York Stock Exchange, with about 1.58 billion shares changing hands, below last year's estimated daily average of 2.18 billion. On the Nasdaq, about 3.1 billion shares traded, well above last year's daily average of 1.63 billion.
Declining stocks outnumbered advancing ones on the NYSE by a ratio of more than 2 to 1, while on the Nasdaq, about two stocks fell for every one that rose.
(Reporting by Chuck Mikolajczak; Editing by Jan Paschal)