Hamilton is the first Ranger to go deep four times in a single game, and just the 16th in baseball history.
In his other at bat, the red hot Hamilton smashed a double to the gap. His 18 total bases in the game set a record for the most in an American League game.
All four home runs were two run shots, with Elvis Andrus scoring on each, and they came off three different Orioles pitchers in the first, third, seventh and eighth innings.
The last player to hit four homeruns in four games was Carlos Delgado in 2003 for the Blue Jays in a late September game against the Tampa Bay Devil Rays.
He said he didn't feel any extra pressure to hit the fourth home run, as he already had accomplished so much.
I just went up like it was any other at-bat because if I don't hit one, Hamilton reasoned, I've still had a really good night.
Hamilton now has homeruns in five of his last six at bats, including a homerun he hit in his final at bat Monday night.
The Rangers centerfielder has been on fire so far this season, hitting .406 with 14 homeruns and 36 RBI. He's on pace for 76 homeruns and 194 RBI for the season.
Check out the video of Hamilton's historic night here.