The Dallas Cowboys and San Francisco 49ers will be the final teams to take the field in Week 1 of the 2019 NFL preseason. They are set to meet Saturday night at Levi’s Stadium, where the Cowboys find themselves as one of the biggest underdogs on the schedule.

San Francisco is laying 4.5 points at home, according to the latest betting line at OddsShark. If Dallas’ recent preseason history is any indication, the Cowboys will have to wait before recording their first victory of the year.

Dallas is on a six-game losing streak in Week 1 of the preseason under head coach Jason Garrett. That includes a 24-21 loss to the 49ers a year ago.

The 49ers are undefeated in their two Week 1 preseason games with Kyle Shanahan as the head coach. San Francisco beat the Kansas City Chiefs 27-17 to kick off their year in 2017.

For the second straight year, the 49ers should have the advantage over the Cowboys.

With Jimmy Garoppolo coming off an ACL tear that ended his 2018 season prematurely, the quarterback won’t play Saturday. San Francisco will still put two serviceable backups on the field as Nick Mullens and C.J. Beathard compete for the No.2 quarterback position.

Mullens led the 49ers with 2,277 passing yards and a 90.8 passer rating last season. He could have a big night against Dallas’ backups.

Jason Garrett Dallas Cowboys
Former head coach Jason Garrett of the Dallas Cowboys reacts in the third quarter against the Los Angeles Rams in the NFC Divisional Playoff game at Los Angeles Memorial Coliseum on January 12, 2019 in Los Angeles, California. Harry How/Getty Images

Dak Prescott isn’t expected to play more than one series for the Cowboys. That means Cooper Rush and Mike White will get the bulk of the time under center.

Rush was good against the 49ers a year ago, going 15-23 for 145 yards and a touchdown. White failed to post a passer rating north of 77.3 in his four preseason appearances last season.

Ezekiel Elliott still isn’t at training camp, though he probably wouldn’t play Saturday if he was practicing with the team.

The Cowboys went winless in the 2018 preseason, scoring 13 points or fewer in three of the four games. The 49ers have never scored fewer than 13 points in eight preseason games under Shanahan.

The over/under between Dallas and San Francisco is 36, per OddsShark. Only three of the 11 preseason games on Week 1 opening night totaled fewer than 36 points.

Prediction: San Francisco over Dallas, 24-13